Notices by Doc Impossible (impossible_phd@hachyderm.io), page 5

@tillybridges That's fucking horrendous. I am speechless.

@tillybridges waylp, time to cancel a registration, I think.

@tillybridges I had assumed you had registered to go to that event. Probably a bit hasty of me to do so. 😅

Hey, y'all, small heads up about Popehat. Thought he was an ally, but I was sadly mistaken.

Not calling for blocks or dog piling (seriously, frickin' don't) or anything. Just... more evidence that cishet white men can't be trusted to contribute to our safety. 😢

ITT: random cishet white dudes arguing for how it's good to be a free speech absolutist and that that doesn't make him not an ally.

... Proving my exact point.

I'm sorry, but I'm a professor of rhetoric, and if you think that the solution to the Firehose of Falsehood is more speech, you literally do not understand, at all, how rhetoric or public discourse works, and you should really shut up and sit the ever-loving fuck down.

Also, please don't mansplain rhetoric to a woman with a PhD in it.

@Are0h couldn't even do that around people who've been here for months.

It really seems like the Fediverse kind of doesn't want people to use the Fediverse, is my impression after today. At least, not anyone who isn't among the techie elite.

Wow. This is actually pretty big news.

The first RCT trial for immediate access to HRT--testosterone to transmascs--has published its findings. In it, 52% of those given immediate access to testosterone had an **IMMEDIATE CESSATION** of their previously-present suicidal ideation, compared to 5% of those given a placebo. A treatment being *ten times* more effective than placebo is pretty much as decisive as it gets.

#FTM #Trans #HRT #Science

https://www.miragenews.com/testosterone-treatment-boosts-mental-health-of-1029278/

@goatsarah @siege In this case, I read it as positive=increase, from a scientific perspective. IE, there's a positive correlation or there's a negative correlation. Not a value judgment, just a denotation that the delta is one where you'd use a +, not a -.

@siege This is very interesting, and the very tight parallels in response between the two main polls actually suggests a third option: that the rectal method of action and uptake chain may differ from what we think it is, regardless of depth, and allo is produced in an unexpected way. A comparison study of oral/rectal MoA's that tracks the full metabolic breakdown chain over time would be fascinating.

Cool work! Thanks for doing it!

@siege Re: possible unexpected metabolic chain: it would certainly be damn weird to get any significant amount of allo out of rectal admin, but it's not unheard-of that something like this has an unexpected result.

Now you've got my noodle cooking.

@siege I guess the question then is whether the allo is indeed the agent responsible for sleepiness in oral uptake. Allo isn't the only metabolic downstream in oral MoA. It's well-observed that allo causes sleepiness, but it's also possible that the sleepiness is part of the downstream *from* allo, and the difference in processing speed is the cause for drowsiness. Could just be subclinical in rectal because of the *rate* of decay.

@siege I mean, aside from literally any other considerations, it's a lot easier to take orally. In my experience as a technical writer, never underestimate the massive power of user laziness.

@siege @TonyaMarie I will say, as someone on oral, it was prog that made me feel really and truly like a woman. Estrogen made me feel like I belonged in my body, but prog made that body feel like a woman's body. I loooove it.

So, you think you might, maybe, possibly be trans, huh?

Yeah, that’s scary as hell, isn’t it?

Questioning your #gender is hard, scary, and is often really, really confusing. This week on #StainedGlassWoman, we're presenting a scientific, systematic process to help you find a real answer to that question--and I'll explain the science at every step.

So come on by and maybe find the answer you've been looking for.

#trans #transgender #mtf #ftm #nonbinary #science

https://stainedglasswoman.substack.com/p/how-to-figure-out-if-youre-trans