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@siege I guess the question then is whether the allo is indeed the agent responsible for sleepiness in oral uptake. Allo isn't the only metabolic downstream in oral MoA. It's well-observed that allo causes sleepiness, but it's also possible that the sleepiness is part of the downstream *from* allo, and the difference in processing speed is the cause for drowsiness. Could just be subclinical in rectal because of the *rate* of decay.