:gnu:+bonifartius 𒂼𒄄@p @lanodan @hj @Hoss @ProfessionalPetFoodTaster @gentoobro @mangeurdenuage
by the gods:
> Although not clinically relevant, mirtazapine has been found to act as a partial agonist of the κ-opioid receptor at high concentrations (EC50 = 7.2 μM).
> The depressive-like behaviors following prolonged morphine abstinence appear to be mediated by upregulation of the KOR/dynorphin system in the nucleus accumbens, as the local application of a KOR antagonist prevented the behaviors.
mirtapazine is inducing depression while reducing inhibition. great idea!
All GNU social JP content and data are available under the