@snacks @mia @lucy @Jazzcraft @nyx Doubt it's the case for everyone, drugs being so generally idiosyncratic, but, there are pretty good reasons to believe that estrogen might potentiate cannabis via the endocannabinoid system - namely by increasing CB1-receptor expression in the CNS, and inhibiting FAAH transcription (catabolic enzyme responsible for the breakdown of a class of endogenous lipids which includes the two primary endogenous CB receptor agonists, anandamide and 2-AG). (This article provides a good pool of sources on the topic: https://academic.oup.com/endo/article/153/3/1016/2423624?login=false#59384295) Purely anecdotally, I am absolutely personally convinced that estradiol potentiates cannabis substantially, or at least, it can and does for my physiology. I began regularly using it about a year before starting estrogen, and have continued to, and since then achieve far greater effects from much smaller doses than I ever had before - which is why I looked into this in the first place. I've had to adjust my dosing accordingly, but, I've not noticed anything really detrimental about it - actually, it's quite nice lol, very modest amounts of weed can last me crazy long.