Conversation

Notices

Embed this notice
:blobcatflower: (methyltheobromine@netzsphaere.xyz)'s status on Tuesday, 30-Jul-2024 15:52:26 JST :blobcatflower:

how does dxm mix with weed and nitrous

In conversation about 4 months ago from netzsphaere.xyz permalink
- Embed this notice
  snacks (snacks@netzsphaere.xyz)'s status on Tuesday, 30-Jul-2024 15:52:13 JST snacks
  in reply to
  @mia @nyx @lucy @Jazzcraft how do you 2 just cinstantly trip on weed, is that somehow related to estradiol???
  
  In conversation about 4 months ago permalink
- Embed this notice
  miauz genyau (mia@movsw.0x0.st)'s status on Tuesday, 30-Jul-2024 15:52:15 JST miauz genyau
  in reply to
  - ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  - Jasmine
  @nyx @lucy @Jazzcraft strange closed-eye visuals (panic-inducing), difficulty recognizing objects, fucked-up short-term memory making me jump randomly at nothing, seeing terrifying faces in random patterns of visual noise, restless legs, paralyzed voice
  
  it was p fucked up
  
  In conversation about 4 months ago permalink
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:16 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  - miauz genyau
  - Jasmine
  @mia @lucy @Jazzcraft how so?
  
  In conversation about 4 months ago permalink
- Embed this notice
  miauz genyau (mia@movsw.0x0.st)'s status on Tuesday, 30-Jul-2024 15:52:17 JST miauz genyau
  in reply to
  - ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  - Jasmine
  @nyx @lucy @Jazzcraft idk how but the weed on its own gave me a dph nightmare trip 🥴
  
  In conversation about 4 months ago permalink
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:19 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  - Jasmine
  @lucy @Jazzcraft yeah I was just making a joke
  
  In conversation about 4 months ago permalink
- Embed this notice
  :blobcatflower: (methyltheobromine@netzsphaere.xyz)'s status on Tuesday, 30-Jul-2024 15:52:20 JST :blobcatflower:
  in reply to
  - ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  - Jasmine
  @nyx @Jazzcraft i was "brainwormed" before taking anything. drugs are my cope.
  
  In conversation about 4 months ago permalink
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:21 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  - Jasmine
  @lucy @Jazzcraft no wonder you're so brainwormed, you probably gave yourself brain damage holy fuck
  
  In conversation about 4 months ago permalink
- Embed this notice
  :blobcatflower: (methyltheobromine@netzsphaere.xyz)'s status on Tuesday, 30-Jul-2024 15:52:22 JST :blobcatflower:
  in reply to
  - ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  - Jasmine
  @nyx @Jazzcraft my dph max was 2600mg i think? on top of half a bottle of absinthe.
  i was doing 1200-1600 every weekend for a while.
  i was ~60kg back then too so ld50 should haven been 1200-2400, but ime ymmv dph is very unpredictable. after that last dose i get nausea even from 300mg, can't take it even medicinally lel
  
  i always throw up and dxm and im more sensitive to this stuff. 20 tabs max and i passed out after meeting all kinds of places and creatures i woke up in barf. i did 15-18 tabs twice a week at least for a very lomg time
  
  In conversation about 4 months ago permalink
- Embed this notice
  Jasmine (jazzcraft@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:23 JST Jasmine
  in reply to
  - ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  @nyx @lucy Ah yeaj. I'm sure there's something non psychoactive that works fine for it too, idk much abt it tho.
  
  In conversation about 4 months ago permalink
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:23 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  - Jasmine
  @Jazzcraft @lucy benadryl will supposedly also work if you don't do enough to enter the spider dimension, haven't tried it yet though
  
  In conversation about 4 months ago permalink
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:24 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  - Jasmine
  @Jazzcraft @lucy I just don't do we'd very often unless I have nothing else available because even like a small amount of it will send me into a state of insanity
  
  In conversation about 4 months ago permalink
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:25 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  
  @lucy we'd potentiates DXM and helps with nausea supposedly
  
  In conversation about 4 months ago permalink
- Embed this notice
  Jasmine (jazzcraft@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 15:52:25 JST Jasmine
  in reply to
  - ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  @nyx @lucy I have a friend who took dxm daily for a long time and she said weed helped her a lot with nausea yeaj.
  
  In conversation about 4 months ago permalink
- Embed this notice
  :blobcatflower: (methyltheobromine@netzsphaere.xyz)'s status on Tuesday, 30-Jul-2024 15:57:50 JST :blobcatflower:
  in reply to
  @snacks @mia @Jazzcraft @nyx it does hit different at least there's tons of anecdotes
  
  In conversation about 4 months ago permalink
  
  snacks likes this.
- Embed this notice
  miauz genyau (mia@movsw.0x0.st)'s status on Tuesday, 30-Jul-2024 15:57:56 JST miauz genyau
  in reply to
  @snacks @nyx @lucy @Jazzcraft probably not but i wouldn't be surprised
  
  In conversation about 4 months ago permalink
  
  snacks likes this.
- Embed this notice
  Jasmine (jazzcraft@social.xenofem.me)'s status on Tuesday, 30-Jul-2024 17:25:33 JST Jasmine
  in reply to
  @snacks @mia @lucy @nyx I think it's more to do with life experiences & individual brain chemistry than anything else. I managed to get estradiol about 3 months ago and quit smoking daily 2 months ago so I do have a 1 month period where I noticed I was getting a little whackier but from what I could tell this was an experiential combination of my newfound euphoria interacting with my bombastic style rather than anything chemical.
  
  In conversation about 4 months ago permalink
  
  snacks likes this.
- Embed this notice
  𝕳𝖊𝖝𝖞𝖓🦑:labrys-chaostar: (nepetalactone@social.xenofem.me)'s status on Thursday, 01-Aug-2024 13:57:46 JST 𝕳𝖊𝖝𝖞𝖓🦑:labrys-chaostar:
  in reply to
  @snacks @mia @lucy @Jazzcraft @nyx Doubt it's the case for everyone, drugs being so generally idiosyncratic, but, there are pretty good reasons to believe that estrogen might potentiate cannabis via the endocannabinoid system - namely by increasing CB1-receptor expression in the CNS, and inhibiting FAAH transcription (catabolic enzyme responsible for the breakdown of a class of endogenous lipids which includes the two primary endogenous CB receptor agonists, anandamide and 2-AG). (This article provides a good pool of sources on the topic: https://academic.oup.com/endo/article/153/3/1016/2423624?login=false#59384295) Purely anecdotally, I am absolutely personally convinced that estradiol potentiates cannabis substantially, or at least, it can and does for my physiology. I began regularly using it about a year before starting estrogen, and have continued to, and since then achieve far greater effects from much smaller doses than I ever had before - which is why I looked into this in the first place. I've had to adjust my dosing accordingly, but, I've not noticed anything really detrimental about it - actually, it's quite nice lol, very modest amounts of weed can last me crazy long.
  In conversation about 4 months ago permalink
  Attachments
  1. Domain not in remote thumbnail source whitelist: oup.silverchair-cdn.com
    
    Minireview: Endocannabinoids and Gonadal Hormones: Bidirectional Interactions in Physiology and Behavior
    
    Endocannabinoids act as a major neuromodulatory system in a variety of physiological and behavioral functions. Three major lines of evidence suggest that t
  snacks likes this.
- Embed this notice
  ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving: (nyx@social.xenofem.me)'s status on Thursday, 01-Aug-2024 13:58:44 JST ??? 妛彁 :xf_nyxsigil: :xf_nyxdisapproving:
  in reply to
  @nepetalactone @snacks @Jazzcraft @lucy @mia really interesting. I think a lot of it comes down to both how potent we'd is for someone depending on their physiology and then how it affects them mentally is also an idiosyncratic thing. like the thing that mia described is what I experience pretty much every time I do a we'd unless I do like a really tiny amount, and I'd always been confused by how basically everyone else cannot relate and basically treats we'd as being on the same level as cigarettes or alcohol of how casually they can do it
  
  In conversation about 4 months ago permalink
  
  snacks likes this.

Public

Conversation

Notices

Feeds