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   Eric Topol (erictopol@mstdn.social)'s status on Friday, 02-Feb-2024 06:55:09 JST Eric Topol

   The XBB.1.5 "updated" Covid vaccine booster provided ~54% increased protection *against symptomatic infections* (including vs. JN.1 variant) compared with not getting it.

   https://cdc.gov/mmwr/volumes/73/wr/mm7304a2.htm?s_cid=mm7304a2_e&ACSTrackingID=USCDC_921-DM121333&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20February%201%2C%202024&deliveryName=USCDC_921-DM121333

   • HistoPol (#HP) 🥥 🌴 repeated this.
   • Embed this notice
     Kinene (c_merriweather@social.linux.pizza)'s status on Friday, 02-Feb-2024 06:55:16 JST Kinene

     in reply to

     @erictopol How long does the vaccine last, and will there be an updated version for the spring?

     HistoPol (#HP) 🥥 🌴 repeated this.
   • Embed this notice
     Peter Butler (peterbutler@mas.to)'s status on Friday, 02-Feb-2024 06:55:27 JST Peter Butler

     in reply to

     • Kinene

     @c_merriweather @erictopol

     Short answer is "Studies suggest that COVID-19 vaccines are most effective during the first three months after vaccination”

     https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/covid-19-vaccine-what-you-need-to-know

     Longer answer is more complicated. A meta-analysis found that protection was about 30% 9 months after a booster:

     https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2804451

   • Embed this notice
     HistoPol (#HP) 🥥 🌴 (histopol@mastodon.social)'s status on Friday, 02-Feb-2024 06:58:15 JST HistoPol (#HP) 🥥 🌴

     in reply to

     • Peter Butler
     • Kinene

     @peterbutler @c_merriweather @erictopol

     #Covid19 #Vaccination

     This being so, what is the optimal interval for the next #booster shot, if you had all up to last year if you are not in a particularly vulnerable group, still 6 months?

   • Embed this notice
     Sam (samohtmas@mastodon.social)'s status on Friday, 02-Feb-2024 07:32:34 JST Sam

     in reply to

     • Peter Butler
     • HistoPol (#HP) 🥥 🌴
     • Kinene

     @HistoPol @peterbutler @c_merriweather @erictopol #COVID You asked wha tthe optimal time is for the next booster?

     Based on the 54% effectiveness reported for JN.1 at 2 months, a shot a month should about do it, provided FDA and CDC would allow it.

     The current vaccine is no longer effective for personal protection, other than against severe disease and death. And that won't last 6 months either. More likely 3.

     It is essential to take other measures to protect yourself ( masks and isolation).

   • Embed this notice
     HistoPol (#HP) 🥥 🌴 (histopol@mastodon.social)'s status on Friday, 02-Feb-2024 07:45:24 JST HistoPol (#HP) 🥥 🌴

     in reply to

     • Peter Butler
     • Kinene
     • Sam

     @samohTmaS
     "Based on the 54% effectiveness reported for JN.1 at 2 months, a shot a month should about do it, provided FDA and CDC would allow it. "

     Apart from a probably increasing vaccination risk, would there even be a new vaccine (variant) every month?

     If your probability holds true, 54% at 2 months, 30% after 9 months is astonishingly good still.

     @peterbutler @c_merriweather @erictopol

   • Embed this notice
     Sam (samohtmas@mastodon.social)'s status on Friday, 02-Feb-2024 09:16:34 JST Sam

     in reply to

     • Peter Butler
     • HistoPol (#HP) 🥥 🌴
     • Kinene

     @HistoPol @peterbutler @c_merriweather @erictopol

     #COVID

     Variants are constantly developing. And hybrids. That is what this virus does - mutate and hybridize. To be far enough different to be a problem takes many months - usually. No guarantees.

     It would be ridiculous to do monthly vaccination. But that is just a measure about how inadequate this vaccine is now - six months since it was released.

     We need new vaccines more frequently to keep up with the virus. And to be over 90% effective.