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  1. Embed this notice
    goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 09:11:13 JST goatsarah goatsarah

    Apparently weird incel types think oestrogen is responsible for women’s sex drive.

    I suspect it would blow their minds if they ever found out that the hormone most involved in making women horny is actually testosterone.

    They act like we’re a different species or something. We all have the same set of receptors, more or less, guys. That’s why medical transition is even possible.

    In conversation Monday, 03-Jul-2023 09:11:13 JST from thegoatery.dyndns.org permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 09:27:27 JST goatsarah goatsarah
      in reply to

      It gets worse for them. Estradiol, the main human oestrogen, is a metabolite of testosterone. The body makes it by converting testosterone into it. They are very, very similar molecules. The main difference is that testosterone has one carbonyl group and one hydroxyl group, and estradiol replaces that carbonyl with a second hydroxyl.

      But anyway: implications for the poor super-straight, “women are a mysterious lovely feminine species” incel types are as follows: all that super feminine oestrogen came from nasty dirty masculine testosterone, and some of their own very male masculine “I love beer and farting” testosterone is routinely converted into sissy emasculating oestrogen (like, if it weren’t, they literally would not have a skeleton).

      Oh, and if the idea of dating women with highish testosterone levels freaks them out, then the way to avoid that is to seek out trans women. Most of us post transition have almost none, and our oestrogen is usually produced from plant sources, going nowhere near any testicular-cooties action.

      But we won’t sleep with them either. So sad.

      In conversation Monday, 03-Jul-2023 09:27:27 JST permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 09:40:31 JST goatsarah goatsarah
      in reply to
      Being serious here, it would likely be much better if we stopped gendering gonadal steroids quite so much. The physical characteristics we regard as “male” and “female” are just the result of variances in endocrine system mixes which aren’t as polar as most people assume, and actually overlap, and short of direct reproduction, you can program nearly any human body to develop pretty much any of these different phenotype expressions: just change the mix. Trans people do it all the time. The number of people who assume that, eg, trans women’s tits are all implants (they aren’t) and can’t lactate (they can) is sad. Surely it’s better if we all understand our own biology a bit better?
      In conversation Monday, 03-Jul-2023 09:40:31 JST permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 18:13:54 JST goatsarah goatsarah
      in reply to
      • Alisdair Calder McGregor

      @A_C_McGregor I mean, this isn’t particularly advanced. It’s just “hypothalamus makes GnRH, pituitary receives GnRH and makes LH, gonads receive LH and make testosterone, testosterone encounters aromatise and turns into oestrogen, hypothalamus notices testosterone and oestrogen and makes less GnRH in response”

      A makes B makes C makes D makes less A 🤷🏻♀️

      In conversation Monday, 03-Jul-2023 18:13:54 JST permalink
    • Embed this notice
      Alisdair Calder McGregor (a_c_mcgregor@topspicy.social)'s status on Monday, 03-Jul-2023 18:13:55 JST Alisdair Calder McGregor Alisdair Calder McGregor
      in reply to

      @goatsarah the reason the Terven are so insistent on "Basic Biology" as an argument is that they failed Advanced Biology.

      In conversation Monday, 03-Jul-2023 18:13:55 JST permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 18:14:45 JST goatsarah goatsarah
      in reply to
      • Alisdair Calder McGregor
      @A_C_McGregor and without C, you are less inclined to do sexytimes, and without D your bones fall to bits.
      In conversation Monday, 03-Jul-2023 18:14:45 JST permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 18:15:20 JST goatsarah goatsarah
      in reply to
      • Alexandra Lanes
      @ajlanes I think that’s literally the definition of a hormone.
      In conversation Monday, 03-Jul-2023 18:15:20 JST permalink
    • Embed this notice
      Alexandra Lanes (ajlanes@mastodon.online)'s status on Monday, 03-Jul-2023 18:15:21 JST Alexandra Lanes Alexandra Lanes
      in reply to

      @goatsarah The big realisation for me was that none of these hormones actually do anything in themselves. They’re just messengers.

      In conversation Monday, 03-Jul-2023 18:15:21 JST permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Monday, 03-Jul-2023 18:58:53 JST goatsarah goatsarah
      in reply to
      • Alexandra Lanes
      • Richard Gadsden
      • Adam
      @pseudomonas @ajlanes @po8crg yeah. AIUI, histamine used to be considered a hormone until its mechanism of action was better understood and it was realised that it is actually a neurotransmitter
      In conversation Monday, 03-Jul-2023 18:58:53 JST permalink
    • Embed this notice
      Richard Gadsden (po8crg@wandering.shop)'s status on Monday, 03-Jul-2023 18:59:05 JST Richard Gadsden Richard Gadsden
      in reply to
      • Alexandra Lanes

      @goatsarah @ajlanes As long as it's not in the brain, then it's a neurotransmitter.

      In conversation Monday, 03-Jul-2023 18:59:05 JST permalink
    • Embed this notice
      Adam (pseudomonas@mastodon.social)'s status on Monday, 03-Jul-2023 18:59:05 JST Adam Adam
      in reply to
      • Alexandra Lanes
      • Richard Gadsden

      @po8crg @goatsarah @ajlanes even then, you still have hormones. neurotransmitters are defined functionally rather than geographically

      In conversation Monday, 03-Jul-2023 18:59:05 JST permalink
    • Embed this notice
      Marc-André Delsuc (ma_delsuc@fediscience.org)'s status on Monday, 03-Jul-2023 23:43:05 JST Marc-André Delsuc Marc-André Delsuc
      in reply to

      @goatsarah
      To make it even funnier:
      Hormones act thru "hormones receptors" which are proteins - coded in our genes as all proteins.
      The testosterone receptor is actually coded on the X chromosome ( check at https://en.wikipedia.org/wiki/Androgen_receptor ) - the female chromosome - which means that women have 2 copies of it while men only one !

      In conversation Monday, 03-Jul-2023 23:43:05 JST permalink

      Attachments

      1. Domain not in remote thumbnail source whitelist: upload.wikimedia.org
        Androgen receptor
        The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen-regulated genes are critical for the development and maintenance of the male sexual phenotype. Function Effect on development In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct...
      goatsarah likes this.
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Tuesday, 04-Jul-2023 03:09:17 JST goatsarah goatsarah
      in reply to
      • Llwynog
      @llwynog “Hi. I’ve started T. I’m just going into the bathroom for … reasons. I will be out when I am hypoglycaemic, with friction burns”
      In conversation Tuesday, 04-Jul-2023 03:09:17 JST permalink
    • Embed this notice
      Llwynog (llwynog@eupolicy.social)'s status on Tuesday, 04-Jul-2023 03:09:18 JST Llwynog Llwynog
      in reply to

      @goatsarah or TERFs who say that testosterone in trans men a) kills libido and b) it makes it impossible to orgasm. Tell me you've never spoken to any trans men without explicitly saying so 😂

      In conversation Tuesday, 04-Jul-2023 03:09:18 JST permalink
    • Embed this notice
      goatsarah (goatsarah@thegoatery.dyndns.org)'s status on Tuesday, 04-Jul-2023 05:25:22 JST goatsarah goatsarah
      in reply to
      • Llwynog
      @llwynog A man's gotta do what a man's gotta do.
      In conversation Tuesday, 04-Jul-2023 05:25:22 JST permalink
    • Embed this notice
      Llwynog (llwynog@eupolicy.social)'s status on Tuesday, 04-Jul-2023 05:25:24 JST Llwynog Llwynog
      in reply to

      @goatsarah honestly, I know trans guys who, during the first months on T, got into trouble for missing lectures and being late to work because they were...busy 😅

      In conversation Tuesday, 04-Jul-2023 05:25:24 JST permalink

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