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<blockquote style="position: relative; padding-left: 55px;"><section><a href="https://fediscience.org/users/ma_delsuc/statuses/110650611819051751">Marc-André Delsuc (ma_delsuc@fediscience.org)'s status on Monday, 03-Jul-2023 23:43:05 JST</a><a href="https://fediscience.org/@ma_delsuc" title="ma_delsuc@fediscience.org"><img src="https://gnusocial.jp/avatar/143358-48-20230703144305.webp" width="48" height="48" alt="Marc-André Delsuc" style="position: absolute; left: 0; top: 0;">Marc-André Delsuc</a><div><a href="https://thegoatery.dyndns.org/display/8a89e8f8-1264-a218-e5b1-19b141255145" rel="in-reply-to">in reply to</a><ul><li></ul></div></section><article><p><a href="https://thegoatery.dyndns.org/profile/goatsarah">@goatsarah</a> <br>To make it even funnier:<br>Hormones act thru "hormones receptors" which are proteins - coded in our genes as all proteins.<br>The testosterone receptor is actually coded on the X chromosome ( check at <a href="https://en.wikipedia.org/wiki/Androgen_receptor" rel="nofollow noreferrer">https://en.wikipedia.org/wiki/Androgen_receptor</a> ) - the female chromosome - which means that women have 2 copies of it while men only one !</p></article><footer><a rel="bookmark" href="https://gnusocial.jp/conversation/1720855#notice-3392131">In conversation</a><time datetime="2023-07-03T23:43:05+09:00" title="Monday, 03-Jul-2023 23:43:05 JST">Monday, 03-Jul-2023 23:43:05 JST</time> <span>from <span><a href="https://fediscience.org/@ma_delsuc/110650611819051751" rel="external" title="Sent from fediscience.org via ActivityPub">fediscience.org</a></span></span><a href="https://fediscience.org/@ma_delsuc/110650611819051751">permalink</a><h4>Attachments</h4><ol><li><article><header><div>Domain not in remote thumbnail source whitelist: upload.wikimedia.org</div><h5><a href="https://en.wikipedia.org/wiki/Androgen_receptor">Androgen receptor</a></h5><div></div></header><div>The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen-regulated genes are critical for the development and maintenance of the male sexual phenotype.Function
Effect on development
In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct...</div><footer></footer></article></li></ol></footer></blockquote>

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Marc-André Delsuc (ma_delsuc@fediscience.org)'s status on Monday, 03-Jul-2023 23:43:05 JSTMarc-André Delsuc
in reply to
- goatsarah
@goatsarah
To make it even funnier:
Hormones act thru "hormones receptors" which are proteins - coded in our genes as all proteins.
The testosterone receptor is actually coded on the X chromosome ( check at https://en.wikipedia.org/wiki/Androgen_receptor ) - the female chromosome - which means that women have 2 copies of it while men only one !
In conversationMonday, 03-Jul-2023 23:43:05 JST from fediscience.orgpermalink
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  Androgen receptor
  The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen-regulated genes are critical for the development and maintenance of the male sexual phenotype. Function Effect on development In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct...

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