@p @NEETzsche @mint I've seen few python wheels precompiled for musl, after all it's basically just few lines in the CI.
One I very rarely see is non-x86 binaries and typically it's just for arm, so no need to even get into obscure architectures.

systemd on the other hand… you can avoid most of it but you'll probably end up with systemd-udev and systemd-tmpfiles in a desktop system (At least there's https://github.com/illiliti/libudev-zero/ but other than quick tests on Alpine where it's packaged I haven't used it)

dbus so far I've managed to entirely get rid of it but you do need to abandon few programs and patch some others.