Justinian I established the patriarch of Rome as being the prime patriarch, by his own Justinian Code (specifically in Novels, section 131), given parts at a time from 529 to sometime after 534. This was the basis of law in continental European powers until Napoleon's Code over a thousand years later. This is the first establishment of that primacy over any other patriarch, after many (and rejected attempts at such) claims beforehand by previous patriarchs of Rome--those whom began to desire to be called Father, to be "more authoritative", to be "the vicar of Christ."

This is the same Justinian I that changed the laws and times (again, established the ruling Justinian Code and introduced a new calendar), was the 11th legitimate emperor of the Byzantines, following 10 legitimate before, subdued 3 rebelling kings (namely, subdued Agila in Spain, Gelimer in North Africa, Vitiges and Totila (one succeeded the other mid-campaign, same crown) in Italy).

In other words, Justinian I was the little horn of Daniel's chapter 7 vision.

Daniel 7:23-26

>Thus he said, The fourth beast shall be a fourth kingdom upon earth, which shall be diverse from all the kingdoms, and shall devour the whole earth, and shall tread it down, and break it in pieces. And as for the ten horns, out of this kingdom shall ten kings arise: and another shall arise after them; and he shall be diverse from the former, and he shall put down three kings. And he shall speak words against the Most High, and shall wear out the saints of the Most High; and he shall think to change the times and the law; and they shall be given into his hand until a time and times and half a time. But the judgment shall be set, and they shall take away his dominion, to consume and to destroy it unto the end.

Now, Justinian I did not live a time and times and half a time--but his law did.
In 1798, Napoleon's troops marched into Rome. The pope was overthrown. In 1804 Napoleon crowned himself, rather than by authority of any pope as had been so for centuries till the day. Napoleon introduced his new code for European powers.
The time and times and half a time were fulfilled.