@killyourfm
So, x11 has only one screen, and fakes multiple screens making a big one. So it only allows for one type of scaling.
Wayland does allow independent scaling but not fractional scaling (yet), but KDE works around it by rendering at 200% and then scaling it back.
That said, I have it working exactly like you want: KDE Wayland screen 1440p 100% + 4k 150%
The only windows that didn't scale were the XWayland windows, which KDE fixed in the latest release.