@xianc78 @TerminalAutism Basically, if you don't need to use Gnome, KDE, or Cinnamon, and are perfectly fine with a DE like Xfce, MATE, LXQt/LXDE, or just about any WM, you shouldn't worry too much about it.
Perhaps if you're running a server and the default package manager doesn't provide init scripts for these, you can easily write your own ones too.

But apart from Gnome, KDE, and Cinnamon, I don't think you'd find any issues anywhere, and even notice a performance boost.