Conversation

Notices

Embed this notice
BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Tuesday, 12-Nov-2024 01:24:39 JST BowserNoodle ☦️
- Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
@jeffcliff what's your thoughts on the researcher self injecting viruses into tumors?

mdpi.com/2076-393X/12/9/958
In conversation about 10 days ago from poa.st permalink
Attachments
1. Domain not in remote thumbnail source whitelist: pub.mdpi-res.com
  
  An Unconventional Case Study of Neoadjuvant Oncolytic Virotherapy for Recurrent Breast Cancer
  
  from Beata Halassy
  
  Intratumoural oncolytic virotherapy may have promise as a means to debulk and downstage inoperable tumours in preparation for successful surgery. Here, we describe the unique case of a 50-year-old self-experimenting female virologist with locally recurrent muscle-invasive breast cancer who was able to proceed to simple, non-invasive tumour resection after receiving multiple intratumoural injections of research-grade virus preparations, which first included an Edmonston-Zagreb measles vaccine strain (MeV) and then a vesicular stomatitis virus Indiana strain (VSV), both prepared in her own laboratory. The intratumoural virus therapy was well tolerated. Frequent imaging studies and regular clinical observations documenting size, consistency and mobility of the injected tumour demonstrate that both the MeV- and VSV-containing parts of the protocol contributed to the overall favourable response. Two months after the start of the virus injections, the shrunken tumour was no longer invading the skin or underlying muscle and was surgically excised. The excised tumour showed strong lymphocytic infiltration, with an increase in CD20-positive B cells, CD8-positive T cells and macrophages. PD-L1 expression was detected in contrast to the baseline PD-L1-negative phenotype. The patient completed one-year trastuzumab adjuvant therapy and remains well and recurrence-free 45 months post-surgery. Although an isolated case, it encourages consideration of oncolytic virotherapy as a neoadjuvant treatment modality.
- Embed this notice
  John_Darksoul (john_darksoul@poa.st)'s status on Tuesday, 12-Nov-2024 01:27:06 JST John_Darksoul
  in reply to
  - Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
  @BowsacNoodle @jeffcliff COVID SAVES LIVES!
  
  In conversation about 10 days ago permalink
- Embed this notice
  Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧 (jeffcliff@shitposter.world)'s status on Tuesday, 12-Nov-2024 02:50:49 JST Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
  in reply to
  - John_Darksoul
  @John_Darksoul @BowsacNoodle modifying covid to do work for us & removing its ability to replicate, given its binding to ACE2 and ability to infiltrate mitochondria is definitely on the table. Like HIV, it's going to be an available tool to biological research going forward
  
  In conversation about 10 days ago permalink
  
  BowserNoodle ☦️ likes this.
- Embed this notice
  Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧 (jeffcliff@shitposter.world)'s status on Tuesday, 12-Nov-2024 02:51:29 JST Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
  in reply to
  
  @BowsacNoodle while this specific paper is mdpi TWIV talked a little about this in passing in one of the episodes 59-62. It seems promising , and the sort of thing that it's amazing how little research as of 2009 there was into it --- definnitely one of those things that if we don't destroy ourselves as a species will probably turn into something, like chemotherapy, that helps get cancers under control
  
  In conversation about 10 days ago permalink
  
  BowserNoodle ☦️ likes this.
- Embed this notice
  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Tuesday, 12-Nov-2024 03:04:19 JST BowserNoodle ☦️
  in reply to
  - Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
  @jeffcliff Seems like this is a potential paradigm shift. Instead of progressively damaging the body and immune system via chemotherapy before trying something like this, she opted to work in reverse and leverage the healthy immune system. It's the kind of table flip that, even if not a one size fits all situation, could be used to justify some more novel studies that present ethical constraints prohibit.
  
  In conversation about 10 days ago permalink
- Embed this notice
  Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧 (jeffcliff@shitposter.world)'s status on Tuesday, 12-Nov-2024 03:10:36 JST Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
  in reply to
  
  @BowsacNoodle no kidding. I don't understand it enough to know why it wouldn't work anyway
  
  In conversation about 10 days ago permalink
  
  BowserNoodle ☦️ likes this.
- Embed this notice
  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Tuesday, 12-Nov-2024 03:15:22 JST BowserNoodle ☦️
  in reply to
  - Jeff "never puts away anything, especially oven mitts" Cliff, Bringer of Nightmares 🏴‍☠️🦝🐙 🇱🇧🧯 🇨🇦🐧
  @jeffcliff Here's my TLDR from another post.
  Some key points I thought were fascinating but didn't put in the TLDR:
  >Tumor swelled off the bat (probably from white blood cells going after viruses). Impure viral strains (not fancy lab grade and was DIY in house). Frequency of injections was high and flipped between the two viruses (kept immune response high and mitigation effects strong). Tumor receeded from muscle it had infiltrated. Viruses shrinking tumors was known for 100+ years).
  poa.st/objects/eefafdcd-b6b4-47c9-b8ae-7924e00af6f0
  In conversation about 10 days ago permalink
  Attachments
  1. Untitled attachment

Public

Conversation

Notices

Feeds