Hate to be "that guy" again, but there's another edge case that breaks the Litespeed cache fix for the Activitypub WP plugin.
When Pixelfed fires off ActivityPubFetchService.get, it sends an Accept header of:
"application/activity+json, application/ld+json"
Although this is matched in the ActivtyPub plugin, it isn't matched in the Litespeed Cache fix. With the same effects as before.
I've amended the RewriteCond to match the plugin regex for now. That seems to work.