My primary problem with running on Debian comes down to this:
Stable: How old do you like your software?
Testing: It usually works
Unstable: You like down time, don't you?
I used to run Redhat, back before it was Redhat Enterprise. I installed RedHat back when one of the language choices in the install was "redneck." I ran Wordperfect for Linux on Redhat 5.1.
And then I suffered three back-to-back rpm database corruptions in about six weeks.
So I moved to Debian Testing. And ran that for some time. Eventually I wanted to run a non-open-source backup program from Veritas and it really, really didn't like running on Debian (even had issues running on Sid), but ran fine on Ubuntu.
So I switched to Ubuntu for a desktop. And then I bailed on Ubuntu because of Gnome3.
And ended up on Mint.