I think I could happily live in any major Asian city, but not many on this side of the world. San Francisco is the smallest city I’ve ever lived in (I don’t consider Monterey a city). I think I could do Seattle and Vancouver. Definitely New York City.
Big enough cities with proximity to food and cultures I like AND nonstop flights to Asia are more important to me than being the homeowner of some home in a place I could never fit in in.