@cwebber I manage multiple PC and VPS with it. Basically like it because of guix and in particular the model of service extension for configuration, and only thing I'm not happy with is slowness (of guix in general).
I use gpg with sops-guix/password-store for secrets. Well, sops is not really used for home (I use it only for private keys or alike which goes to the system config), as most secrets in my home config are just passwords. Most things I want to sync works with syncthing.
I still have bit chunk of dotfiles that are in some stow/chezmoi structure which is not particularly "guixy" for them to be applicable to machines I do not own.