@cwebber I use it across all my non-server computers and love it. Same base config across all of them with a few tweaks for e.g. work-only/sensitive configs
I haven't really worked out secrets management very well beyond using Bitwarden for web stuff. Outside that I've just got authinfo files on each machine so far, and use things like remotepasseval in offlineimap. But secrets management has been a perennial frustration with Guix for me and I feel like Guix really needs a common answer for it