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@futurebird I love reading and thinking about this, though I'm not technically educated enough to make a determination. I just want to believe.

I think you and others have mentioned that one big problem ignored in most sci fi is the fact that humans can't survive (or perhaps just can't thrive) without some very specific conditions: gravity in a specific range, our atmosphere, the stuff we need to eat (including a bunch of little detail food things that turn out to be pretty important), sunlight, a diurnal cycle, and then all the social and psychological needs, concerns about managing a little (or big) society including prevention of violence, resource allocation, education/skills, etc... and then we will need to do more than just survive. "Is not life more than the body?" etc.

I still think it can be done, but I also think that, ultimately, we will need to hack ourselves (significantly more than we already have) as well as building special habitats.