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    Charlie Stross (cstross@wandering.shop)'s status on Sunday, 03-Nov-2024 05:35:45 JSTCharlie StrossCharlie Stross
    in reply to
    • Winchell Chung ⚛🚀
    • K.G. Jewell
    • Joachim Boaz

    @KG_Jewell @SFRuminations @nyrath No definite information to add EXCEPT that 1937 was the year of the Elixir Sulfanilamide mass-poisoning tragedy that led to the FDA after 1938: https://en.wikipedia.org/wiki/Elixir_sulfanilamide

    In conversationabout 7 months ago from gnusocial.jppermalink

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      Elixir sulfanilamide
      Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have killed more than 100 people. The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act, which significantly increased the Food and Drug Administration's powers to regulate drugs. History Aside from the Pure Food and Drug Act of 1906 and the Harrison Act of 1914 banning the sale of some narcotic drugs, there was no federal regulatory control in the United States of America for drugs until Congress enacted the 1938 Food, Drug, and Cosmetic Act in response to the elixir sulfanilamide poisonings. In 1937, S. E. Massengill Company, a pharmaceutical manufacturer, created an oral preparation of sulfanilamide using diethylene glycol (DEG) as the solvent or excipient, and called the preparation "Elixir Sulfanilamide". DEG is poisonous to humans and other mammals, but Harold Watkins, the company's chief pharmacist and chemist, was not aware of this. (Although the first case of a fatality from the related ethylene glycol...
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