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Charlie Stross (cstross@wandering.shop)'s status on Sunday, 03-Nov-2024 05:35:45 JST Charlie Stross
in reply to
@KG_Jewell @SFRuminations @nyrath No definite information to add EXCEPT that 1937 was the year of the Elixir Sulfanilamide mass-poisoning tragedy that led to the FDA after 1938: https://en.wikipedia.org/wiki/Elixir_sulfanilamide
In conversation about 7 months ago from gnusocial.jp permalink
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  Elixir sulfanilamide
  
  Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have killed more than 100 people. The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act, which significantly increased the Food and Drug Administration's powers to regulate drugs. History Aside from the Pure Food and Drug Act of 1906 and the Harrison Act of 1914 banning the sale of some narcotic drugs, there was no federal regulatory control in the United States of America for drugs until Congress enacted the 1938 Food, Drug, and Cosmetic Act in response to the elixir sulfanilamide poisonings. In 1937, S. E. Massengill Company, a pharmaceutical manufacturer, created an oral preparation of sulfanilamide using diethylene glycol (DEG) as the solvent or excipient, and called the preparation "Elixir Sulfanilamide". DEG is poisonous to humans and other mammals, but Harold Watkins, the company's chief pharmacist and chemist, was not aware of this. (Although the first case of a fatality from the related ethylene glycol...
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  K.G. Jewell (kg_jewell@wandering.shop)'s status on Sunday, 03-Nov-2024 05:35:52 JST K.G. Jewell
  in reply to
  - Winchell Chung ⚛🚀
  - Joachim Boaz
  @SFRuminations @nyrath
  I wouldn't trust them to have waited for the connection to be established. Note they stopped advertising it after an FTC action in 1939. https://www.google.com/books/edition/Federal_Trade_Commission_Decisions/SYB0ltfREnoC?hl=en&gbpv=0
  In conversation about 7 months ago permalink
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  1. 01721. Vendor-Advertiser—Medicinal Preparations.—Louis J. Schuck, an individual, Jamaica, N. Y., vendor-advertiser was engaged in sell- ing certain medicinal preparations designated Kandu Tabs, Kandu Delight, Kandu Jelly, and the formula for “Sex Energy Creating Tonie,” and has sold a preparation designated, Nox-Alco, and agreed in soliciting the sale of and selling its said products, in interstate commerce, to cease and desist from representing directly or otherwise : 1 [...]7 I'he respondent has definitely discontinued the advertising for and e of the preparation designated “Nox-Alco.” (Mar. 26, 1937.) |
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    Federal Trade Commission Decisions
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  Joachim Boaz (sfruminations@wandering.shop)'s status on Sunday, 03-Nov-2024 05:35:58 JST Joachim Boaz
  in reply to
  - Winchell Chung ⚛🚀
  @nyrath Don't think it can be. According to the article you linked, it wasn't until 1937 that its properties connected to alcoholism were established.
  
  In conversation about 7 months ago permalink
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  Winchell Chung ⚛🚀 (nyrath@spacey.space)'s status on Sunday, 03-Nov-2024 05:35:59 JST Winchell Chung ⚛🚀
  in reply to
  - Joachim Boaz
  @SFRuminations
  Perhaps Disulfiram? (1930s)
  https://en.m.wikipedia.org/wiki/Disulfiram
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    Disulfiram
    
    Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart failure, unconsciousness, convulsions, and death. In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. When the dehydrogenase enzyme is inhibited, acetaldehyde builds up, causing unpleasant side effects (see Disulfiram-alcohol reaction). Disulfiram should be used in conjunction with counseling and support...
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  Joachim Boaz (sfruminations@wandering.shop)'s status on Sunday, 03-Nov-2024 05:36:08 JST Joachim Boaz
  
  "Will mail FREE TRIAL of harmless NOXALCO. Can be given secretly in food or drink for Whiskey, Beer, Gin, Home Brew, Wine, Moonshine, etc."
  Umm... anyone know more about what this stuff actually is?
  An advertisement in Amazing Stories (April 1932)
  #scifi #sciencefiction #science #medicine #pseudoscience #pseudomedicine #1930s
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  1. Ad for NOXALCO. "Will mail FREE TRIAL of harmless NOXALCO. Can be given secretly in food or drink for Whiskey, Beer, Gin, Home Brew, Wine, Moonshine, etc. Your request for FREE TRIAL will bring trial supply by return mail and full $2.00 treatment which you may try under our 30 day refund guarantee."
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