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Day 010 of the Multiple Sclerosis Study
(Compound Day 7) Thursday on 2024-09-12
Groningen, Netherlands (GMT+1)

07:15 Intravenous catheter (Insert)
07:30 ECG (3x measurements)
07:40 Wellbeing (Pre dose)
07:40 Vital signs
08:05 Transfer bloodtubes
08:05 Blood sampling

• PK: Sample 17
• PL PD 2-AG: Sample 106
• Expl BM: Sample 202
• SR PD 2-AG: Sample 309

08:10 CSF sampling

• PD CSF: Sample 502
• Collection 2

08:10 Transfer CSF tubes
08:10 Supervision

• Start category 2 for CSF sampling

09:10 Supervision

• Stop category 2 for CSF sampling (1 hour after the CSF sampling of the last subject)

09:10 Breakfast (Start on bed)
09:40 Dose (R07268489 or placebo)
09:40 Dase check
09:40 Water fast (Start)
11:40 Water fast (Stop)
11:40 Morning snack
13:10 Lunch
15:00 Afternoon snack
15:00 Intravenous catheter (Check)
17:30 Dinner
19:00 Wellbeing
20:30 Evening snack
22:00 Intravenous catheter (Check)

07:15-Now No effects
08:10-Now increasing lower back pain (CSF)
20:40-21:33 Strong emotional outbursts

~08:10 (written afterwards)
I was just in there for two minutes. I had no shivering, no fear. They said I was done the moment I thought that the procedure annoyed me. The doctor used a thinner needle, a different procedure, and recommended I lie in bed longer in order to prevent headaches. I laid in bed not for one hour, but for three.

15:00
Playing boardgames with my 4 study peers

20:35
This morning cannula sucks, they have to give me another one. I wanted to move this to the next day.

20:55
I am crying real tears because the cannula just hurt a million times more. During the whole process I'd be super in pain and the assistant doing the cannula just stopped moving (whilst staying stationary in a hurting position) and asked me to calm down. I was breathing heavily and got super disoriented. I asked to have a moment beforehand to prepare myself, because I was feeling a bit hypersensitive, she didn't really understand and only said “I will warn you before the needle comes”. I was breathing so heavily saying it hurts, her reassurance was simply “calm down”. Both of my arms are hard to use now. I feel super disoriented and have trouble finding the words of what I want to say to the doctors.

I've suddenly gotten this feeling that I'm being used? I felt so weird about myself. The way I was seeing my body detached from myself was very strong again, for those who rember. I've looked at my right arm, three small needle wounds and a bigger red dot which was from the previous cannula. I looked at my left arm and saw / felt the mess from this morning (blood went places inside my arm), as well as several needle wounds. This sudden and overwhelming feeling of everything being very wrong came over me. In that moment, I cried.

The fact a small frustration feels like the saddest thing ever is why I cried. I can hence say that I still have strong effects. In the past, these side effects never interfered with medical actions. The following days will be interesting, because I have to cope with feeling everything more intense and dramatic.

21:08
Other assistant's now telling me something with my new cannula is wrong again (it was hard to insert the salt solution, also my arm was numb after doing so. Please just do it tomorrow?? The drugs are letting me feel EVERYTHING, a lot more.

21:33
Ive calmed down a lot! I'll have a nice cup of sleep now, thx :))