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Day 009 of the Multiple Sklerosis Study
(Compound Day 6) Wednesday on 2024-09-11
Groningen, Netherlands (GMT+1)

07:30 Wellbeing (Pre dose)
08:40 ECG (3x measurements)
08:40 Vital signs (BP, HR)
08:55 Blood sampling

• PK: Sample 16
• Clinical chemistry (see SSL)

08:55 Transfer bloodtubes
09:10 Breakfast (Start)
09:40 Dose (RO7268489 or placebo)
09:40 Dose check
09:40 Water fast (Start)
11:40 Water fast (Stop)
11:40 Morning snack
13:10 Lunch
15:30 Afternoon snack
18:30 Dinner
19:00 Wellbeing
21:30 Evening snack

(not personally recorded)

07:15 (written afterwards)
I awoke with the sudden realization that I was still high. I woke up with about 30% of what I experienced the day prior - to me personally this strength was how I had positively used marihuana before. So, I woke up with a feeling that I would usually have when taking edibles. At that point I was fairly convinced I didn't have the placebo.

09:40 (written afterwards)
Whilst still high on a level I'd usually only have when eating an edible, I took another one of the vials with this medicine. That would only lead to the concentration of RO7268489 in my blood. Obviously I would only get higher.

14:00 (written afterwards)
My parents visited me and I showed them around. Still thinking that I'd be just as functioning here as anywhere else, as I did two days ago, I scheduled a work meeting on this very day. During / after the panic attack yesterday, I didn't think about canceling this event. I also didn't want to cancel it on the same day. That meant that I needed to do a business meeting whilst being on ~130% of the dose that made me have a panic attack yesterday.

The meeting went okay, especially because I came clear at the end when everything was done and dusted. During the meeting, I would sometimes lose focus and was incapable of concentrating, I'd pause sometimes for a very long time, because I had a small blackout.

16:00 (written afterwards)

As my parents were gone, I got back to my bed and tried if I can work on some things, but even writing this report would've been too much. So, I just took it easy and calmed down.