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@dalias oh, I see. Well, thing is: these are not like PCI USB cards (or built in port) which work as long as you have standard UHCI or OHCI drivers (some even exist for DOS).
The CH375 is a small microcontroller which on one side speaks to a USB device and on the other exposes an emulated peripheral on the ISA bus.
i.e. the handling of USB devices doesn't happen inside the host computer, but inside the card itself, thus you can use it an meager ancient 8bit hardware (e.g. Book8088)