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@nyx @kyouu main benefits of prog (+metabolites) are neurological. other than that it doesn’t seem to do all that much in transfem hrt. think it’s worth it though. if nothing else it drastically reduces alzheimer risk and helps a lot with stroke recovery (mostly via allopregnanolone)

not sure whether going through first-pass metabolism is better or worse; available lecture indicates that oral leads to good levels of allopregnanolone (which really seems to be the most interesting metabolite), so i’m inclined to prefer that

if you dose high enough that way you also get a very pleasant high. it’s potentiated by methylphenidate for me but that may just be my weird ADD brain (in contrast, opioids generally cause mania for me)