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@ironchamber @anildash @mathowie
There was actually a fair body of ergonomics research on this, but the literature I'm familiar with is pre-web. I'd have to look up for specifics (I still have that ergonomics topics reader from school) but my recollection is that they worked OK for a small set of users with very narrow needs, but were a major detriment to power users. IIRC there was speculation that it would also tend to narrow the options that were used through a negative feedback loop.