In my opinion, #Guix is an overkill for anything except computer science research. I think an approach that has better chances to succeed is reusing the OCI ecosystem and in particular using #ComposeFS for a per-file deduplication, that is important for large datasets. The missing piece for me it's a package manager for knowledge i.e. that links papers, datasets, source code for both calculations and documents (LaTeX, #Typst etc) in a graph of dependencies, citations etc.