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@thomasfuchs @x2ero I'm not sure about the pointlessness (on a global scale, sure, but on a personal one, maybe not), but that would not affect if determinism is true, at least not without an argument why everything being pointless could not be possible, right?
Regarding quantum effects: I agree, there probably is something like true randomness which could affect brains (and maybe computers too?). Would it be appropriate to call that partially random input to an otherwise deterministic system?