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    feld (feld@bikeshed.party)'s status on Saturday, 13-Jan-2024 05:26:52 JSTfeldfeld
    in reply to
    • Hyolobrika
    • Craig Groeschel
    @Hyolobrika @craig_groeschel it's fairly well covered in here from what I can tell. The individual memory T-cells don't need to live for years, only their clones

    > One way to resolve this apparent paradox is to view cellular behaviour from a kinetic viewpoint. As Michie et al. observed in 1992, “… memory is maintained by long-lived clones rather than individual cells with a long lifespan” [17]. The pivotal concept here is that it is the population that must be long-lived, not necessarily the individual cell. Hence, we need to refer to “cells conferring long-lived-memory”, rather than “long-lived memory cells”. This concept is widely accepted and very familiar to people studying the dynamics of T cell memory but has been slow to be adopted into some areas of immunology.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371741/
    In conversationSaturday, 13-Jan-2024 05:26:52 JST from bikeshed.partypermalink

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    1. Domain not in remote thumbnail source whitelist: www.ncbi.nlm.nih.gov
      Human T Cell Memory: A Dynamic View
      Long-term T cell-mediated protection depends upon the formation of a pool of memory cells to protect against future pathogen challenge. In this review we argue that looking at T cell memory from a dynamic viewpoint can help in understanding how memory ...
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