Honestly my money is on them just refusing to hear the case.
Colorado was never going to be a winning situation for him. If SCOTUS doesn't hear the case, it won't apply nationally, and until it's brought up in another court, it's in legal limbo. Other districts can agree with it, or disagree with it, but they don't have to obey it- whereas if there is an official ruling that's it.
As for justices, I think two of those are possibles, but I wouldn't bet on it.