@SapientPearwood @Evil_Bender @feralphilosophernc @pyrate for certain things "natural" is a good rule of thumb, but drugs is one to be careful with. The deathcap mushroom is "natural" but I wouldn't suggest ingesting it. Unless there has been selective pressure to make a natural drug conform to humans, there is no added safety and the only advantage that it can confer is people having used them for a long time.