@TonyaMarie @Impossible_PhD Another option may down to how some cis women respond differently to Allopreg. When they studied groups of women who had PMDD against women who didnt, the group who didnt, got the expected sedative result while the PMDD group had an paradoxically opposite effect wiith increased active respone in the amygdala. It's im pretty sure why progesterone is such a confusing hormone in terms of trans research, for some people the allopreg is good for mental health, for some its neutral and others its seems to be very bad.