Hi Ken, welcome!
There are a lot of blind people on here. Hopefully accessibility is better here than on Twitter, but please say something if it isn't.
Here are a couple of screen reader guides by blind users which may be helpful in getting started:
https://www.starshipchangeling.net/mastodon/
https://blindjournalist.wordpress.com/2022/05/01/mastodon-for-writers-and-readers/