Absolutely.
In the end, it really doesn’t matter that much, because we can see eachother’s toots, pleromas, etc. But when it comes to features, there are some big differences.
I personally use my own Rebased (Pleroma) instance just for my family, my friends and me as some sort of client for the Fediverse, so the federation is the main part for me, which means I could be at home with Mastodon, Pleroma, Misskey or whatever just fine.
I personally prefer Pleroma and it’s forks, because it’s much lighter on resources, compared to - for example - Mastodon. Pleroma is so much easier to maintain and run, as it has far fewer moving parts.