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@moses_izumi As someone who hasn't dealt with WINE code or DOS, I would still say... borderline impossible, but you can maybe reuse pieces.
WINE depends on there being a Linux kernel underneath for forking processes, scheduling threads, and dealing with inter-process communication. None of that exists on MS-DOS, so you'd need to, at minimum, supply a whole kernel-like part that does these things, and then also patch it all across the WINE codebase.