I switched to tmux soon after the initial release, roughly 17 years ago.
less than three months ago, I finally pushed through accepting ctrl+b as the control character. I had started using GNU Screen maybe a year prior to the release of tmux, and fought against ctrl+b in favor of Screen's ctrl+a for nearly 17 years.
I finally changed.
It was nothing. I avoided change for 17 years, and for nothing. The change took me hours, not even days.
Reason: ctrl+a does other useful shit.