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mhoye (mhoye@mastodon.social)'s status on Saturday, 23-Nov-2024 09:44:57 JST mhoye

jfc this paper
"Profound similarities between highly nAChR affine toxins (i.e., from snakes of the Ophiophagus (cobra) [...], Rabies lyssavirus [...] strains [...] and Cobratoxin (naja siamensis) [...] and SARS-CoV-2 specific proteins were found by analyzing the toxin’s amino-acid (aa) sequence alignment and comparing it to the motifs in spike glycoprotein (SGP) from SARS-CoV-2."
https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7
In conversation about 5 days ago from mastodon.social permalink
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1. Our group recently described the crucial relevance of autonomic balance for the severity of COVID-19 disease courses (Leitzke et al. 2020; Leitzke and Schönknecht 2021) and highlighted the significance of nicotinic acetylcholine receptors (nAChRs) for the limiting regulation of cytokine liberation and virus replication on the transcriptional level, restricting NF-KB action along the cholinergic anti-inflammatory pathway (CAP) (Leitzke et al. 2020; Leitzke and Schönknecht 2021). Profound similarities between highly nAChR affine toxins (i.e., from snakes of the Ophiophagus (cobra) and Bungarus genera, the G-ectodomains of three Rabies lyssavirus (formerly Rabies virus) (RABV) strains (Changeux et al. 2020) or muscarinic toxin-like protein and Cobratoxin (naja siamensis) (Farsalinos et al. 2020)) and SARS-CoV-2 specific proteins (Farsalinos et al. 2020; Changeux et al. 2020) were found by analyzing the toxin’s amino-acid (aa) sequence alignment and comparing it to the motifs in spike glycoprotein (SGP) from SARS-CoV-2 (Farsalinos et al. 2020; Changeux et al. 2020).
  https://files.mastodon.social/media_attachments/files/113/527/877/826/116/062/original/65254c0b9d2fd8f5.png
2. Domain not in remote thumbnail source whitelist: static-content.springer.com
  
  Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration? - Bioelectronic Medicine
  
  from Leitzke, Marco
  
  Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other unspecific physical complaints. Several investigators could demonstrate that the SARS-CoV-2 related spike glycoprotein (SGP) attaches not only to ACE-2 receptors but also shows DNA sections highly affine to nicotinic acetylcholine receptors (nAChRs). The nAChR is the principal structure of cholinergic neuromodulation and is responsible for coordinated neuronal network interaction. Non-intrinsic viral nAChR attachment compromises integrative interneuronal communication substantially. This explains the cognitive, neuromuscular and mood impairment, as well as the vegetative symptoms, characterizing post-COVID-19 syndrome. The agonist ligand nicotine shows an up to 30-fold higher affinity to nACHRs than acetylcholine (ACh). We therefore hypothesize that this molecule could displace the virus from nAChR attachment and pave the way for unimpaired cholinergic signal transmission. Treating several individuals suffering from post-COVID-19 syndrome with a nicotine patch application, we witnessed improvements ranging from immediate and substantial to complete remission in a matter of days.
- Michał "rysiek" Woźniak · 🇺🇦, Charlie Stross and jwz repeated this.
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  mhoye (mhoye@mastodon.social)'s status on Saturday, 23-Nov-2024 09:44:57 JST mhoye
  in reply to
  
  Paraphrased, that reads "At a molecular level, parts of the Covid19 virus look and seemingly behave a lot like cobra venom and rabies."
  Turns out being "covid cautious" is just a revealed preference for not wanting strangers to sneeze rabies and snake venom analogues into your lungs.
  Wear a mask.
  
  In conversation about 5 days ago permalink

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