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Our group recently described the crucial relevance of autonomic balance for the severity of COVID-19 disease courses (Leitzke et al. 2020; Leitzke and Schönknecht 2021) and highlighted the significance of nicotinic acetylcholine receptors (nAChRs) for the limiting regulation of cytokine liberation and virus replication on the transcriptional level, restricting NF-KB action along the cholinergic anti-inflammatory pathway (CAP) (Leitzke et al. 2020; Leitzke and Schönknecht 2021). Profound similarities between highly nAChR affine toxins (i.e., from snakes of the Ophiophagus (cobra) and Bungarus genera, the G-ectodomains of three Rabies lyssavirus (formerly Rabies virus) (RABV) strains (Changeux et al. 2020) or muscarinic toxin-like protein and Cobratoxin (naja siamensis) (Farsalinos et al. 2020)) and SARS-CoV-2 specific proteins (Farsalinos et al. 2020; Changeux et al. 2020) were found by analyzing the toxin’s amino-acid (aa) sequence alignment and comparing it to the motifs in spike glycoprotein (SGP) from SARS-CoV-2 (Farsalinos et al. 2020; Changeux et al. 2020).