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   نبي الحيوان (mono@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:09:20 JST نبي الحيوان
   fascinated by the recent discovery that the major cause of ageing isn't telomeres but literally just your gut enzymes leaking at a linear rate digesting the rest of your body and all animals with digestive tracts share this stupid and relatively easy to fix design flaw
   • 翠星石 likes this.
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:09:18 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to
     @mono Maybe that side effect exists to avoid unregulated cellular growth in cells that are too old.
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     نبي الحيوان (mono@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:09:19 JST نبي الحيوان

     in reply to
     https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312149
     
     Abstract
     
     The mechanism that triggers the progressive dysregulation of cell functions, inflammation, and breakdown of tissues during aging is currently unknown. We propose here a previously unknown mechanism due to tissue autodigestion by the digestive enzymes. After synthesis in the pancreas, these powerful enzymes are activated and transported inside the lumen of the small intestine to which they are compartmentalized by the mucin/epithelial barrier. We hypothesize that this barrier leaks active digestive enzymes (e.g. during meals) and leads to their accumulation in tissues outside the gastrointestinal tract. Using immune-histochemistry we provide evidence in young (4 months) and old (24 months) rats for significant accumulation of pancreatic trypsin, elastase, lipase, and amylase in peripheral organs, including liver, lung, heart, kidney, brain, and skin. The mucin layer density on the small intestine barrier is attenuated in the old and trypsin leaks across the tip region of intestinal villi with depleted mucin. The accumulation of digestive enzymes is accompanied in the same tissues of the old by damage to collagen, as detected with collagen fragment hybridizing peptides. We provide evidence that the hyperglycemia in the old is accompanied by proteolytic cleavage of the extracellular domain of the insulin receptor. Blockade of pancreatic trypsin in the old by a two-week oral treatment with a serine protease inhibitor (tranexamic acid) serves to significantly reduce trypsin accumulation in organs outside the intestine, collagen damage, as well as hyperglycemia and insulin receptor cleavage. These results support the hypothesis that the breakdown of tissues in aging is due to autodigestion and a side-effect of the fundamental requirement for digestion.
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:14:33 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     @binkle @mono I agree.
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     binkle (binkle@clubcyberia.co)'s status on Tuesday, 19-Nov-2024 04:14:34 JST binkle

     in reply to

     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     @mangeurdenuage @mono yeah i was thinking this too. it's a fascinating discovery but i wouldn't be too quick to assume it has no purpose
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:18:09 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     @mono @binkle
     >we already have a different thing for that.
     That doesn't mean it isn't part of it, no ?
     
     Side though.
     I wonder what would the data difference be, if any, between a human on an ancestral diet and "modern" diet.
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     نبي الحيوان (mono@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:18:10 JST نبي الحيوان

     in reply to

     • binkle
     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     @binkle @mangeurdenuage
     
     chemical damage to the organs isnt a regulation mechanism for cells, we already have a different thing for that.
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:20:12 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     • Nudhul
     @Nudhul @binkle @mono
     "All disease begins in the gut" or "Health starts in the gut".
     --Hippocrates
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     Nudhul (nudhul@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:20:13 JST Nudhul

     in reply to

     • binkle
     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     @binkle @mangeurdenuage @mono live by the stomach die by the stomach
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     binkle (binkle@clubcyberia.co)'s status on Tuesday, 19-Nov-2024 04:20:14 JST binkle

     in reply to

     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     @mono @mangeurdenuage the specific point is tangential. the general point is that you shouldn't assume you have all the information about a system just because you've discovered something new about it
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     binkle (binkle@clubcyberia.co)'s status on Tuesday, 19-Nov-2024 04:38:21 JST binkle

     in reply to

     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     • HenryNFren
     @HenryNFren @mangeurdenuage @mono if im understanding correctly its more like we could develop therapies to slow or halt aging or at least certain aspects of the aging process. im not sure how much good it would do for people who already have that damage
     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: likes this.
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     HenryNFren (henrynfren@clubcyberia.co)'s status on Tuesday, 19-Nov-2024 04:38:22 JST HenryNFren

     in reply to

     • binkle
     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     @binkle @mono @mangeurdenuage is the idea here you will start solving heart deterioration/heart attacks/liver failure of old people from this discovery? this is an old person's cure is it not? and probably not related to alot of other ailments
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 04:40:35 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     • HenryNFren
     @binkle @HenryNFren @mono It could make things worse from my perspective. So far the only treatment that works for aging for almost everybody is oxygen therapy and you can further that with hyperbaric oxygen therapy, and you get even better results by combining hyperbaric oxygen therapy with keto diet.
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 05:04:56 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     • HenryNFren
     @binkle @HenryNFren @mono I'm thinking and the ramifications of this new discovery can be quite important.
     If stomach acids/enzymes cause/triggers unnecessary autophagy. Then that means that leaky guts, which cause various deceases that goes from Autism, Alzheimer etc.. almost everything could be linked (and I'm saying linked not caused) to that since in a lot of case when leaky guts are fixed symptoms are reduced and even eliminated.
     Re-population of various microbes and diet balance means that the stomach doesn't need to produce as much as previously acids/enzymes and that the wall of the stomach would restrain from leaking more of these substances.
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 05:08:12 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     • HenryNFren
     @HenryNFren @binkle @mono If this turns out to be correct, and if I did not misunderstood anything, then that means it's another proof that we have to go back to our ancestral diet and stop eating stuff that requires our stomachs to work even more to avoid being sick.
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     mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius: (mangeurdenuage@shitposter.world)'s status on Tuesday, 19-Nov-2024 05:37:38 JST mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:

     in reply to

     • binkle
     • HenryNFren
     @HenryNFren @binkle @mono
     > I don't think you can go on keto and limit trypsin.
     That isn't the goal of keto either. Just like the GAPS protocol it's a method to find back proper food health.
     And if that health manifest itself from regenerating the stomach's cell walls then that might lead to reduced stomach enzymes leaking. Or that you populated your gut with some microbes that even furthers that.
     Time will tell.
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     HenryNFren (henrynfren@clubcyberia.co)'s status on Tuesday, 19-Nov-2024 05:37:39 JST HenryNFren

     in reply to

     • binkle
     • mangeurdenuage :gnu: :trisquel: :gondola_head: 🌿 :abeshinzo: :ignucius:
     @mangeurdenuage @binkle @mono I don't think you can go on keto and limit trypsin. Trypsin is integral to breaking down proteins, in fact it's been used for eliminating excess protein accumulations causing some types of arthritis. I imagine you limit Trypsin via this tranexamic acid for two weeks and simultaneously go on a keto diet you will have massive digestive issues.