Sounds promising. Hope it works.
Vaccine breakthrough means no more chasing strains https://news.ucr.edu/articles/2024/04/15/vaccine-breakthrough-means-no-more-chasing-strains
Sounds promising. Hope it works.
Vaccine breakthrough means no more chasing strains https://news.ucr.edu/articles/2024/04/15/vaccine-breakthrough-means-no-more-chasing-strains
@WarnerCrocker Finally! Fingers crossed it works.
@WarnerCrocker If anyone reading this has a working link to the paper can you post it? The one in the press release is giving a DOI error.
Interesting write up, but the link to the actual paper in the article goes to a not found page, and searching pnas.org I can't find the paper by author name either. All of the write ups on it go to the same not found page.
If anyone finds a valid link to this paper, could you please post it?
Title is apparently:
Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells
Thank you!
@WarnerCrocker It would be interesting to know which viruses are included and those that are excluded.
Sounds like overoptimistic PR and reminds of a professor of mine who once characterized those type of feel-good "news":
"The cure of a disease is the cure of the disease in mice."
Give me clinical data from big RCTs and it could be a different ballgame.
@SRLevine @StillIRise1963 @WarnerCrocker
After having spent too much time on it, I think the paper might not be released yet. One write up I read said it's dated April 19th.
@StillIRise1963 @WarnerCrocker Thanks, that link works, but it's the press release. I'm looking for the PNAS paper itself, which they link to but the link is broken, which I'm assuming involves a silly typo in the DOI, but I'm not going to figure it out by guessing.
https://news.ucr.edu/articles/2024/04/15/vaccine-breakthrough-means-no-more-chasing-strains
@MCDuncanLab @SRLevine Either that or it’s a PR play to hype the release. Not unusual if so.
I think the press release jumped the embargo by a couple of hours or a day. It'll probably come out soon.
@brhfl @SRLevine @StillIRise1963 Guessing this article is probably part of a PR push prior to the pub date of the article.
@SRLevine @StillIRise1963 @WarnerCrocker there doesn’t seem to be any reference to it on the pnas site, and another article seemingly based on the press release gave a publication date of 04-19, so it seems possible the doi link simply isn’t active yet?
@WarnerCrocker "This new strategy would eliminate the need to create all these different shots, because it targets a part of the viral genome that is common to all strains of a virus." Doesn't this just create huge evolutionary pressure, resulting in mutations that change the "part of the viral genome that is common to all strains of a virus" enough so that the vaccine is no longer effective against it? I have no expertise, but this is a university press release, not the paper itself, and press releases tend to be overly optimistic about new research.
@not2b As I said, souonds promising. Hope it works.
@memerman @BE @StillIRise1963 @WarnerCrocker Thanks for the heads up that the paper was now available (looks like it wasn't until sometimes yesterday). Link if anyone else wants to read it: https://www.pnas.org/doi/10.1073/pnas.2321170121
(if it's behind a paywall and someone reading this wants a copy let me know, I can't tell since UCI pays for journal access for me anyway)
@BE @SRLevine @StillIRise1963 @WarnerCrocker Interesting paper, but quite different from the press release which promised something more broad. (the paper is a nice demonstration of immunity to a particular mosquito-borne virus in a mouse model, not the respiratory viruses discussed in the press release and certainly not in humans)
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