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   Warner Crocker (warnercrocker@mastodon.social)'s status on Tuesday, 16-Apr-2024 23:00:42 JST Warner Crocker

   Sounds promising. Hope it works.

   Vaccine breakthrough means no more chasing strains https://news.ucr.edu/articles/2024/04/15/vaccine-breakthrough-means-no-more-chasing-strains

   • Embed this notice
     Lydia Schoch (lydiaschoch@mastodon.social)'s status on Tuesday, 16-Apr-2024 23:16:44 JST Lydia Schoch

     in reply to

     @WarnerCrocker Finally! Fingers crossed it works.

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     Sam Levine (srlevine@urbanists.social)'s status on Tuesday, 16-Apr-2024 23:34:21 JST Sam Levine

     in reply to

     @WarnerCrocker If anyone reading this has a working link to the paper can you post it? The one in the press release is giving a DOI error.

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     A Concerned Scientist (be@qoto.org)'s status on Tuesday, 16-Apr-2024 23:34:23 JST A Concerned Scientist

     in reply to

     @WarnerCrocker

     Interesting write up, but the link to the actual paper in the article goes to a not found page, and searching pnas.org I can't find the paper by author name either. All of the write ups on it go to the same not found page.

     If anyone finds a valid link to this paper, could you please post it?

     Title is apparently:

     Live-attenuated virus vaccine defective in RNAi suppression induces rapid protection in neonatal and adult mice lacking mature B and T cells

     Thank you!

   • Embed this notice
     Zilla (zillamon@mastodon.social)'s status on Tuesday, 16-Apr-2024 23:42:35 JST Zilla

     in reply to

     @WarnerCrocker It would be interesting to know which viruses are included and those that are excluded.

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     Lil Meow Meow (lil_meow_meow@mastodon.social)'s status on Tuesday, 16-Apr-2024 23:43:50 JST Lil Meow Meow

     in reply to

     @WarnerCrocker

     Sounds like overoptimistic PR and reminds of a professor of mine who once characterized those type of feel-good "news":

     "The cure of a disease is the cure of the disease in mice."

     Give me clinical data from big RCTs and it could be a different ballgame.

   • Embed this notice
     A Concerned Scientist (be@qoto.org)'s status on Tuesday, 16-Apr-2024 23:47:38 JST A Concerned Scientist

     in reply to

     • StillIRise1963
     • Sam Levine

     @SRLevine @StillIRise1963 @WarnerCrocker

     After having spent too much time on it, I think the paper might not be released yet. One write up I read said it's dated April 19th.

     https://www.eurekalert.org/news-releases/1041168

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     Sam Levine (srlevine@urbanists.social)'s status on Tuesday, 16-Apr-2024 23:47:39 JST Sam Levine

     in reply to

     • StillIRise1963

     @StillIRise1963 @WarnerCrocker Thanks, that link works, but it's the press release. I'm looking for the PNAS paper itself, which they link to but the link is broken, which I'm assuming involves a silly typo in the DOI, but I'm not going to figure it out by guessing.

     Warner Crocker repeated this.
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     StillIRise1963 (stillirise1963@mastodon.world)'s status on Tuesday, 16-Apr-2024 23:47:41 JST StillIRise1963

     in reply to

     • Sam Levine

     @SRLevine @WarnerCrocker

     https://news.ucr.edu/articles/2024/04/15/vaccine-breakthrough-means-no-more-chasing-strains

   • Embed this notice
     Warner Crocker (warnercrocker@mastodon.social)'s status on Wednesday, 17-Apr-2024 00:08:21 JST Warner Crocker

     in reply to

     • Sam Levine
     • MCDuncanLab

     @MCDuncanLab @SRLevine Either that or it’s a PR play to hype the release. Not unusual if so.

   • Embed this notice
     MCDuncanLab (mcduncanlab@mstdn.social)'s status on Wednesday, 17-Apr-2024 00:08:22 JST MCDuncanLab

     in reply to

     • Sam Levine

     @SRLevine @WarnerCrocker

     I think the press release jumped the embargo by a couple of hours or a day. It'll probably come out soon.

   • Embed this notice
     Warner Crocker (warnercrocker@mastodon.social)'s status on Wednesday, 17-Apr-2024 01:15:46 JST Warner Crocker

     in reply to

     • StillIRise1963
     • Sam Levine
     • bri

     @brhfl @SRLevine @StillIRise1963 Guessing this article is probably part of a PR push prior to the pub date of the article.

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     bri (brhfl@digipres.club)'s status on Wednesday, 17-Apr-2024 01:15:47 JST bri

     in reply to

     • StillIRise1963
     • Sam Levine

     @SRLevine @StillIRise1963 @WarnerCrocker there doesn’t seem to be any reference to it on the pnas site, and another article seemingly based on the press release gave a publication date of 04-19, so it seems possible the doi link simply isn’t active yet?

   • Embed this notice
     Joe (not2b@sfba.social)'s status on Wednesday, 17-Apr-2024 01:37:12 JST Joe

     in reply to

     @WarnerCrocker "This new strategy would eliminate the need to create all these different shots, because it targets a part of the viral genome that is common to all strains of a virus." Doesn't this just create huge evolutionary pressure, resulting in mutations that change the "part of the viral genome that is common to all strains of a virus" enough so that the vaccine is no longer effective against it? I have no expertise, but this is a university press release, not the paper itself, and press releases tend to be overly optimistic about new research.

   • Embed this notice
     Warner Crocker (warnercrocker@mastodon.social)'s status on Wednesday, 17-Apr-2024 01:37:12 JST Warner Crocker

     in reply to

     • Joe

     @not2b As I said, souonds promising. Hope it works.

   • Embed this notice
     Sam Levine (srlevine@urbanists.social)'s status on Friday, 19-Apr-2024 02:08:40 JST Sam Levine

     in reply to

     • StillIRise1963
     • A Concerned Scientist
     • Michael Emerman

     @memerman @BE @StillIRise1963 @WarnerCrocker Thanks for the heads up that the paper was now available (looks like it wasn't until sometimes yesterday). Link if anyone else wants to read it: https://www.pnas.org/doi/10.1073/pnas.2321170121

     (if it's behind a paywall and someone reading this wants a copy let me know, I can't tell since UCI pays for journal access for me anyway)

   • Embed this notice
     Michael Emerman (memerman@mstdn.science)'s status on Friday, 19-Apr-2024 02:08:42 JST Michael Emerman

     in reply to

     • StillIRise1963
     • Sam Levine
     • A Concerned Scientist

     @BE @SRLevine @StillIRise1963 @WarnerCrocker Interesting paper, but quite different from the press release which promised something more broad. (the paper is a nice demonstration of immunity to a particular mosquito-borne virus in a mouse model, not the respiratory viruses discussed in the press release and certainly not in humans)

     Warner Crocker repeated this.
   • Embed this notice
     A Concerned Scientist (be@qoto.org)'s status on Friday, 19-Apr-2024 02:08:44 JST A Concerned Scientist

     in reply to

     • StillIRise1963
     • Sam Levine

     @SRLevine @StillIRise1963 @WarnerCrocker

     https://www.pnas.org/doi/10.1073/pnas.2321170121

     Warner Crocker repeated this.