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   🎓 Doc Freemo :jpf: 🇳🇱 (freemo@qoto.org)'s status on Friday, 08-Mar-2024 15:27:23 JST 🎓 Doc Freemo :jpf: 🇳🇱

   Just for fun I decided to do the math to calculate the amount of Ozempic/semiglutide in my system based on the usualy dosing of every 7 days (in red), versus dosing every single day (at 1/7th) the dose (in green).

   The two colors represent the upper and lower limit (it will at the upper limit right after a dose and at the lower limit right before a dose).

   Notice that dosing every day makes for a much more stable concentration. Note this assumes a 1 mg dose (y-axis) and the x-axis is in days. I will start dosing every day tomorrow.

   For those curious I also attached the equation that I calculated (derived) for the half-life. Both in its continuous form and as the summation.

   #Ozempic #Semiglutide #WeightLoss

   • Embed this notice
     Paul Brownjohn (paulos_the_fog@qoto.org)'s status on Friday, 08-Mar-2024 16:11:00 JST Paul Brownjohn

     in reply to

     @freemo

     I also inject semaglutide at the rate of 1mg/week for diabetes rather than weight loss.

     Due to recurrent shortages of the injectable form, my endocrinologist has given me an alternative prescription for an oral version of semaglutide called Rybelsus(14mg/day) taken daily.

     I wonder, firstly, why the injected form is prescribed if an oral form is available and whether the daily oral dose would be more effective than the injection as it would presumably deliver a more stable blood concentration of the medication than the weekly injection.

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     🎓 Doc Freemo :jpf: 🇳🇱 (freemo@qoto.org)'s status on Friday, 08-Mar-2024 23:51:24 JST 🎓 Doc Freemo :jpf: 🇳🇱

     in reply to

     • bedast :diabetes:

     @bedast

     Do you have any information on this crystalization of ozempic as a unique property from glp-1. According to my research thats not how it works at all.

     Glp-1 is not the same chemical as what your body uses. Your body uses glucagon which has a 2 minute half life. Glp stands for "Glucagon like peptide". It is structurally similar to glucagon but has the sites where the enzymes that cleave it act modified so they can no longer break down thr chemical. This means glp is basically like glucagon but with a half life of 7 days not 2 minutes.

     That said the pharmakenetics of compounded semiglutide and ozempic should be identical.

   • Embed this notice
     bedast :diabetes: (bedast@squirrelmob.com)'s status on Friday, 08-Mar-2024 23:51:25 JST bedast :diabetes:

     in reply to

     @freemo This seems to be derived based on a misunderstanding of data and how the drug works when used in the #Ozempic form and not the compounded #semaglutide form.

     Ozempic doesn’t just squirt a concentration of GLP-1 RA into you that is just there for your body to use whenever. It uses technology derived from what we’ve learned about long acting “basal” insulin (once daily rather than mealtime) that causes it to essentially crystalize and slowly dissolve and release the drug over the week time. It’s not a perfect system, but it overlaps well enough that available drug is a bit sinusoidal over the weeks of use.

     If you think it’s better to take a daily dose, check out #Victoza / #liraglutide. It’s made by the same company (Novo Nordisk) but is once daily instead of weekly.

     It’s not really a good idea to try to modify the dosing from the guidelines. It’s worth noting US poison control has had a pretty sharp increase in the last couple of years of Ozempic poisoning calls from people trying to manage the dose on their own.