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Benzene (benzene@poa.st)'s status on Wednesday, 07-Feb-2024 10:03:55 JST Benzene
@AngryWraith it's like when my little cousin said breathing is just setting us in fire slowly and I freaked for a bit because he's right @SK1ZM @BronzeAgeHogCranker

In conversation about 10 months ago from poa.st permalink
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 10:03:55 JST SKiZM :confederate:
  in reply to
  - AngryWraith
  - 🇧🇷🇴🇳🇿🇪🇦🇬🇪🇭🇴🇬🇨🇷🇦🇳🇰🇪🇷
  Technically the only reason we age and die is because the oxygen is just a destructive force to our cells and causes the production of free radicals, which leads to the decay of DNA replication; but the mitochondria requires it to function. Maybe we need a better formula of gases or a different atmosphere to breathe properly 🧐
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:05:35 JST BowserNoodle ☦️
  in reply to
  @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene There's not a better formula. Best we could do is probably stem cells from our early moments and maybe our umbilical cord preserved and find a way to Crispr a purer version of our own DNA onto ourselves later on.
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:09:29 JST BowserNoodle ☦️
  in reply to
  @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene Mitochondrial DNA ages at a different rate than the rest of our body. Few know this.
  
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 10:09:30 JST SKiZM :confederate:
  in reply to
  We need to carve those little mitochondrias out of our cells! :insane:
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:19:51 JST BowserNoodle ☦️
  in reply to
  @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene >Mitochondria differ from all other organelles in animals in having their own DNA (mitochondrial DNA, mtDNA), which in humans encodes 37 genes: 22 tRNAs, 2 rRNAs and 13 protein subunits of the electron transport chain and Complex V/ATP synthase.
  I'm serious though. Increased blood pH (alkalinity) and decreased white blood cells are associated with better mitochondrial copies, but also associated with being young.
  >In the general population, mtDNA copy number measured in peripheral blood has also been shown to be associated with a variety of physiological phenotypes, and to be linked with aging and mortality. For example, higher mtDNA copy number was linked with better physical and mental health status in aged populations.
  Here's the kicker, because this type of language is where all the juicy bits of knowledge that are often "known" by bro science and alt health:
  >It has been speculated that both mtDNA heteroplasmy and copy number may contribute to the aging process, but the effects of mtDNA heteroplasmy and copy number were only discussed separately, thus remaining inconclusive in humans.
  
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 10:19:52 JST SKiZM :confederate:
  in reply to
  Little fuckers hoarding all the oxygen! :soyjak:
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:23:59 JST BowserNoodle ☦️
  in reply to
  @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene They're the reason we can breav
  
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 10:24:00 JST SKiZM :confederate:
  in reply to
  At some point these fuckers crawled inside the multicellular organisms and took over the host. :jew_noticed:
  
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  AngryWraith (angrywraith@poa.st)'s status on Wednesday, 07-Feb-2024 10:25:40 JST AngryWraith
  in reply to
  @BowsacNoodle @SK1ZM @BronzeAgeHogCranker @benzene [Desire to science more intensifies]
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:25:40 JST BowserNoodle ☦️
  in reply to
  @AngryWraith @SK1ZM @BronzeAgeHogCranker @benzene bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4287-0
  In conversation about 10 months ago permalink
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    Independent impacts of aging on mitochondrial DNA quantity and quality in humans - BMC Genomics
    
    from Gu, Zhenglong
    
    Background The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction of mtDNA copy number, both disrupt mitochondrial energetics, and may contribute to aging and age-associated phenotypes. However, there are few genetic and epidemiological studies on the spectra of blood mtDNA heteroplasmies, and the distribution of mtDNA copy numbers in different age groups and their impact on age-related phenotypes. In this work, we used whole-genome sequencing data of isolated peripheral blood mononuclear cells (PBMCs) from the UK10K project to investigate in parallel mtDNA heteroplasmy and copy number in 1511 women, between 17 and 85 years old, recruited in the TwinsUK cohorts. Results We report a high prevalence of pathogenic mtDNA heteroplasmies in this population. We also find an increase in mtDNA heteroplasmies with age (β = 0.011, P = 5.77e-6), and showed that, on average, individuals aged 70-years or older had 58.5% more mtDNA heteroplasmies than those under 40-years old. Conversely, mtDNA copy number decreased by an average of 0.4 copies per year (β = −0.395, P = 0.0097). Multiple regression analyses also showed that age had independent effects on mtDNA copy number decrease and heteroplasmy accumulation. Finally, mtDNA copy number was positively associated with serum bicarbonate level (P = 4.46e-5), and inversely correlated with white blood cell count (P = 0.0006). Moreover, the aggregated heteroplasmy load was associated with blood apolipoprotein B level (P = 1.33e-5), linking the accumulation of mtDNA mutations to age-related physiological markers. Conclusions Our population-based study indicates that both mtDNA quality and quantity are influenced by age. An open question for the future is whether interventions that would contribute to maintain optimal mtDNA copy number and prevent the expansion of heteroplasmy could promote healthy aging.
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:31:09 JST BowserNoodle ☦️
  in reply to
  @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene IDK what vidjagame it was that had mitochondria as the baddies but they're just a part of us at this point. I think all eukaryotes have them but I don't remember.
  
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 10:31:10 JST SKiZM :confederate:
  in reply to
  But at what cost? 🧐
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  Victor_Emmanuel (victor_emmanuel@poa.st)'s status on Wednesday, 07-Feb-2024 10:31:49 JST Victor_Emmanuel
  in reply to
  @BowsacNoodle @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene >Post about hoe esotericism turns into biology hell thread
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:33:54 JST BowserNoodle ☦️
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  @Victor_Emmanuel @SK1ZM @BronzeAgeHogCranker @AngryWraith @benzene
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:36:02 JST BowserNoodle ☦️
  in reply to
  @AngryWraith @SK1ZM @BronzeAgeHogCranker @benzene >Coin clips the oxygen from the red blood cells
  >releases free radicals (section 8 housing) to your nearby cells
  
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  AngryWraith (angrywraith@poa.st)'s status on Wednesday, 07-Feb-2024 10:36:03 JST AngryWraith
  in reply to
  @SK1ZM @BowsacNoodle @BronzeAgeHogCranker @benzene I wonder if AI can make a picture of a jewish mitochondria stealing oxygen and releasing free nigicals.
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:38:15 JST BowserNoodle ☦️
  in reply to
  @benzene @AngryWraith @BronzeAgeHogCranker @SK1ZM I remember some relaxation meditation thing with some granola chick saying "you are a bellows" and explaining things like this. TBQH kind of true.
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 10:42:35 JST BowserNoodle ☦️
  in reply to
  @benzene @AngryWraith @BronzeAgeHogCranker @SK1ZM YOU ARE NOW BREATHING MANUALLY
  
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  Benzene (benzene@poa.st)'s status on Wednesday, 07-Feb-2024 10:42:36 JST Benzene
  in reply to
  @BowsacNoodle
  >you are a bellows
  I'm uncomfortable with how much sense this makes.
  @AngryWraith @BronzeAgeHogCranker @SK1ZM
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 11:18:40 JST BowserNoodle ☦️
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  @AngryWraith @SK1ZM @BronzeAgeHogCranker @benzene
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 11:19:04 JST SKiZM :confederate:
  in reply to
  This guy gets it! Flowering plants only appeared as the dinosaurs died out, since their scaly skin was useless to our plant overlords. The fur from mammals were an excellent method of cross-pollination. 🧐
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  T man :sex: :puffgiga: :puffpowerroll: (theorytoe@ak.kyaruc.moe)'s status on Wednesday, 07-Feb-2024 11:19:04 JST T man :sex: :puffgiga: :puffpowerroll:
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  @SK1ZM @BronzeAgeHogCranker @blankdeblank @AngryWraith @BowsacNoodle @benzene
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 11:19:05 JST SKiZM :confederate:
  in reply to
  The oxygen required by the mitochondria is what produces the free radicals which corrupts the DNA replication process 🧐
  
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  Benzene (benzene@poa.st)'s status on Wednesday, 07-Feb-2024 11:19:05 JST Benzene
  in reply to
  @SK1ZM
  >mfw trees domesticated us
  @BronzeAgeHogCranker @blankdeblank @AngryWraith @BowsacNoodle
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 11:19:06 JST SKiZM :confederate:
  in reply to
  If you read up the thread, I explained how the opposite is true. 🥴
  
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  blankdeblank (blankdeblank@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 11:19:06 JST blankdeblank
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  Hmm I didn't know that I all ways thought it was ours cells copy and it's an imperfect copy and that's why we don't heal as fast when we get older. Because our cells are corrupted which would be like smokers get lung cancer because there lungs cells have to replace themselves more often then people that don't smoke. Same with skin cancer and not protecting yourself from overdoing it.
  
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  blankdeblank (blankdeblank@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 11:19:07 JST blankdeblank
  in reply to
  You need oxygen increasing that makes our bodies function better.
  
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  SKiZM :confederate: (sk1zm@nicecrew.digital)'s status on Wednesday, 07-Feb-2024 11:19:08 JST SKiZM :confederate:
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  I just want to breathe an atmosphere of 100% nitrogen, is that too much to ask. :wojak_depressed:
  
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  moomin (moomin@poa.st)'s status on Wednesday, 07-Feb-2024 11:26:23 JST moomin
  in reply to
  @BowsacNoodle @benzene @AngryWraith @BronzeAgeHogCranker @SK1ZM yes i am
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  AngryWraith (angrywraith@poa.st)'s status on Wednesday, 07-Feb-2024 11:26:23 JST AngryWraith
  in reply to
  @moomin @BowsacNoodle @benzene @BronzeAgeHogCranker @SK1ZM Why does he have a portable nut sack on his right hip?
  
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  BowserNoodle ☦️ (bowsacnoodle@poa.st)'s status on Wednesday, 07-Feb-2024 11:26:23 JST BowserNoodle ☦️
  in reply to
  @AngryWraith @moomin @benzene @BronzeAgeHogCranker @SK1ZM pocket sand
  
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  veff :trash: (veff@poa.st)'s status on Wednesday, 07-Feb-2024 16:35:12 JST veff :trash:
  in reply to
  @BowsacNoodle @AngryWraith @SK1ZM @BronzeAgeHogCranker @benzene I like how this thread started with "mom did you orgasm when I was born" and turned into "mitochondria DNA biomedical analysis"
  
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