Regarding guix: This is is a huge effort, still work in process, anyhow great progress has been achieved in the last months and years. Read more about this at https://guix.gnu.org/de/blog/2023/the-full-source-bootstrap-building-from-source-all-the-way-down/
Regarding #nix, I don't know whether they actually try since they even include blobs provided by others (e.g. proprietary software).
@ahelwer
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