Very good news on the fall booster. The FDA changed course from JN.1 to select KP.2, which in the animal model has a >3-fold induction of neutralizing antibodies vs KP.3, the SARS-CoV2 variant that is on its way to dominance in the US (and causing trouble in multiple countries)
https://www.nbcnews.com/health/health-news/fda-recommends-covid-vaccine-update-target-kp2-strain-rcna157089
Notices by Eric Topol (erictopol@mstdn.social)
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Eric Topol (erictopol@mstdn.social)'s status on Saturday, 15-Jun-2024 08:44:01 JST Eric Topol -
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Eric Topol (erictopol@mstdn.social)'s status on Saturday, 08-Jun-2024 00:34:01 JST Eric Topol The KP.3 variant is taking over in the US, with 2 key mutations beyond JN.1 (F456L and Q493E) at the same time FDA has planned for JN.1 to be the target of the new Covid booster in September. Big mismatch and bad call.
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Eric Topol (erictopol@mstdn.social)'s status on Thursday, 30-May-2024 16:56:49 JST Eric Topol What if there was an antibiotic that doesn't disrupt the gut microbiome?
There is now.
A discovery published at Nature today
https://nature.com/articles/s41586-024-07502-0In conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Sunday, 26-May-2024 09:39:31 JST Eric Topol The process leading to Alzheimer's disease takes about 20 years to develop, giving more than ample opportunity to identify high-risk individuals and change the natural history.
Discussed in the new Ground Truths
https://erictopol.substack.com/p/medical-forecasting
and in this week's Science Magazine
https://www.science.org/doi/10.1126/science.adp7977In conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Tuesday, 21-May-2024 04:43:49 JST Eric Topol The highly pro-inflammatory and pervasive microplastics and nanoplastics: previously found in arteries and associated with increased in heart attacks and strokes, now in all human testes that were assessed.
https://erictopol.substack.com/p/theres-plastic-in-my-plaque
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Eric Topol (erictopol@mstdn.social)'s status on Thursday, 16-May-2024 08:32:35 JST Eric Topol https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00410-X/fulltext
First clinical trial of a pan-coronavirus vaccine , Phase 1 results, looks encouraging
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Eric Topol (erictopol@mstdn.social)'s status on Thursday, 25-Apr-2024 05:39:12 JST Eric Topol An update on H5N1 bird flu from the USDA, CDC, FDA joint briefing session today
https://erictopol.substack.com/p/a-bird-flu-h5n1-status-reportIn conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Wednesday, 24-Apr-2024 08:56:04 JST Eric Topol This isn't good, folks.
I'm not worried about H5N1 transmission to humans (yet) but the USDA pathetic lack of transparency, how long it took for the genomes to be released, lack of testing asymptomatic cattle......
All detracts from "confidence"In conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Friday, 19-Apr-2024 12:12:35 JST Eric Topol A Covid update
https://erictopol.substack.com/p/are-we-flirting-with-a-new-covid
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Eric Topol (erictopol@mstdn.social)'s status on Thursday, 04-Apr-2024 07:54:54 JST Eric Topol Paxlovid didn’t provide any benefit in a placebo-controlled randomized trial in lower risk (mean age 42 years) outpatients with mild-to-moderate Covid
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Eric Topol (erictopol@mstdn.social)'s status on Wednesday, 13-Mar-2024 08:36:38 JST Eric Topol Covid vaccination markedly reduced blood clots, heart attacks, heart failure, stroke and other adverse cardiovascular outcomes, as seen from over 20 million people, about half of whom were vaccinated https://heart.bmj.com/content/early/2024/01/24/heartjnl-2023-323483
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Eric Topol (erictopol@mstdn.social)'s status on Wednesday, 13-Mar-2024 06:45:00 JST Eric Topol Beyond ~30 million excess deaths, "The COVID-19 pandemic caused the most severe drops in life expectancy seen in 50+ years."
https://healthdata.org/research-analysis/library/mortality-life-expectancy-and-population
https://thelancet.com/journals/lancet/article/PIIS0140-6736(24)00476-8/fulltextIn conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Sunday, 10-Mar-2024 16:20:42 JST Eric Topol The dose-response relationship between education and improved survival, quantified for the first time. For each additional year of schooling, an associated reduction of mortality risk of 1.9%, higher with younger ages https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(23)00306-7/fulltext
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Eric Topol (erictopol@mstdn.social)'s status on Wednesday, 06-Mar-2024 01:04:02 JST Eric Topol Diagnosing Alzheimer’s disease with only a blood test (p-tau217) and no symptoms has big (and negative) implications
https://www.nytimes.com/2024/03/04/health/alzheimers-amyloid-diagnosis.html?searchResultPosition=1
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Eric Topol (erictopol@mstdn.social)'s status on Thursday, 29-Feb-2024 20:16:21 JST Eric Topol 2 important large prospective cohort studies of cognitive deficits with Long Covid were just published. I reviewed them in a new Ground Truths post
https://erictopol.substack.com/p/long-covid-and-cognitive-deficits
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Eric Topol (erictopol@mstdn.social)'s status on Thursday, 29-Feb-2024 10:39:48 JST Eric Topol Ultra-processed foods are ultra bad for your health. Consistent evidence of adverse impact for > 30 health outcomes from a comprehensive umbrella review
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Eric Topol (erictopol@mstdn.social)'s status on Monday, 26-Feb-2024 09:20:56 JST Eric Topol If you want to understand how Long Covid affects the brain, or the neuroscience of cancer, there's nobody better than Prof/Dr Michelle Monje to learn from.
https://erictopol.substack.com/p/michelle-monje-the-brain-in-long
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Eric Topol (erictopol@mstdn.social)'s status on Saturday, 24-Feb-2024 02:02:13 JST Eric Topol This week in LongCovid:
✓ Leaky blood-brain barrier
✓ Interferon-γ as a potential biomarker
✓ Persistent infections and >50%⬆️risk
✓ Vaccination protection in adults and kids >40%
✓ Our perspective published in Science
All in the new Ground Truths
https://erictopol.substack.com/p/towards-solving-the-long-covid-puzzleIn conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Friday, 23-Feb-2024 00:00:16 JST Eric Topol Disruption of the blood brain barrier (-> leaky) in #LongCovid in individuals with brain fog
https://nature.com/articles/s41593-024-01576-9
Assessment with MRI, brain-specific S100β protein, RNA-seq indicates dysregulation of clotting system and pro-inflammatory endothelial cellsIn conversation from mstdn.social permalink Attachments
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Eric Topol (erictopol@mstdn.social)'s status on Tuesday, 20-Feb-2024 04:21:21 JST Eric Topol Niacin, the B vitamin that was previously used to improve lipid profiles and reduce the risk of heart disease, promotes arterial inflammation and cardiovascular risk through its metabolites
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