While I'm on Lisp machines, hot take: Lisp is a language of the past. Specifically, it is a language of a past when memory latency was a lot cheaper relative to CPU cycles than it is today. Today it lacks what you could call "mechanical sympathy" for modern systems, unless you do significant code generation transformations.
(And this is not because CPU and system designers are ignoring Lisp. They would love lower memory latency. They just can't get it cheaply.)