That would fail: binary file transfers toss all 256 combos at the port. Compression assured the spread.
In practice, delay +++ delay worked perfectly. I don't think it happened even once to me or anyone I talked to (very large number).
Also the worst that could happen was disconnect; the host could talk to the modem but from the line side, nada.
Modem control and recovery was a deepish art in the FidoNet days. They weren't that determinate when things Went Wrong. And there were like 20 or 50 different modem types in use. Some were just awful. Some were wildly complex. Some could not be used as a BBS incoming.
Getting serial ports with consistent control lines as per anything like rs232 was awful. The damn apple machine had zero handshake lines. Things were wildly inconsistent then.