One minor difference between #Mastodon and #Twitter that always struck in mind:
Over here, I was _never_ mocked for writing " #Pronouns : He/Him" into my profile.
At Twitter, this happened _all_ the time, especially during political discussions - and often accompanied by comments such as:
"Oh, I see - you are one of THEM!", along with claims that I "would never be a real man".
I may be cisgender, but I found this kind of transphobia to be deeply tiring.