John Marshall@regehr @jripley Our genomics library suffered from this on x86-64 a while back: data structures with unaligned uint32_ts crashed when user code was compiled with vectorisation. It was a shame that these uint32_t CIGAR entries weren't aligned in the first place, which I've long used as an example of the perils of bioinformaticians single-handedly designing formats without any input from anyone with a CS background… #ThisIsBioinformatics
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