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<blockquote style="position: relative; padding-left: 55px;"><section><a href="https://genomic.social/users/johnm/statuses/113879703158363271">John Marshall (johnm@genomic.social)'s status on Saturday, 25-Jan-2025 10:43:20 JST</a><a href="https://genomic.social/@johnm" title="johnm@genomic.social"><img src="https://gnusocial.jp/theme/gnusocialjp/default-avatar-stream.png" width="48" height="48" alt="John Marshall" style="position: absolute; left: 0; top: 0;">John Marshall</a><div><a href="https://mastodon.social/@regehr/113879240969197633" rel="in-reply-to">in reply to</a><ul><li><li><a href="https://gnusocial.jp/user/217537" title="jripley@mastodon.social">John Ripley</a></li></ul></div></section><article><p><a href="https://mastodon.social/@regehr">@regehr</a> <a href="https://mastodon.social/@jripley">@jripley</a> Our genomics library suffered from this on x86-64 a while back: data structures with unaligned uint32_ts crashed when user code was compiled with vectorisation. It was a shame that these uint32_t CIGAR entries weren't aligned in the first place, which I've long used as an example of the perils of bioinformaticians single-handedly designing formats without any input from anyone with a CS background… <a href="https://genomic.social/tags/ThisIsBioinformatics" rel="tag">#ThisIsBioinformatics</a></p><p><a href="https://github.com/samtools/htslib/issues/400" rel="nofollow noreferrer">https://github.com/samtools/htslib/issues/400</a></p></article><footer><a rel="bookmark" href="https://gnusocial.jp/conversation/4443526#notice-8695056">In conversation</a><time datetime="2025-01-25T10:43:20+09:00" title="Saturday, 25-Jan-2025 10:43:20 JST">about a year ago</time> <span>from <span><a href="https://genomic.social/@johnm/113879703158363271" rel="external" title="Sent from genomic.social via ActivityPub">genomic.social</a></span></span><a href="https://genomic.social/@johnm/113879703158363271">permalink</a></footer></blockquote>

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John Marshall (johnm@genomic.social)'s status on Saturday, 25-Jan-2025 10:43:20 JSTJohn Marshall
in reply to
- John Regehr
- John Ripley
@regehr @jripley Our genomics library suffered from this on x86-64 a while back: data structures with unaligned uint32_ts crashed when user code was compiled with vectorisation. It was a shame that these uint32_t CIGAR entries weren't aligned in the first place, which I've long used as an example of the perils of bioinformaticians single-handedly designing formats without any input from anyone with a CS background… #ThisIsBioinformatics
https://github.com/samtools/htslib/issues/400
In conversationabout a year ago from genomic.socialpermalink

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