My parents 2009 F350 had the engine block crack after ~150k miles. The repair bill including a new crate engine is going to be north of $30k. In the last few years they had big bills for the high pressure fuel pump and the front axle swingarm bushings and suspension components.
It's still less expensive though to throw a new engine into it than buy a new diesel truck. An equivalent truck at the base model trim runs $80k MSRP before tax and delivery fees.