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I keep receiving invitations to predatory conferences, I decided lately to start reporting all of them to the domain provider to take them down.
Fellow researchers, reporting a domain to provider and isp takes you 2 minutes; if we all do it we'll maybe stop receiving all their bullshit.

Today I even received a reply:

Dear Heidi,

I’m unsure what you are replying to, I never asked to be a speaker. Unfortunately, contacting me now for a conference in February is a bit too late.

Its unfortunate you don’t provide your full name, it would have been useful.

Since I have seen your domain was registered in July, I suppose yours is quite a new business and I guess this is your first conference.

I have contacted GoDaddy and your ISP to prevent your spam to be pushed out and hopefully so they take down your website.

I figured that rather than moving all these emails to spam every day I’m better off just getting your websites to go down. I’d rather go through a bunch of DDOS of your domains rather than keep receiving spam.

Have a good evening and stop this bullshit.

Reply:

Thank you for your reply. As you are into Drug desigining, we thought you might be interested to join us at Boston. Instead of reporting, you could have just let us know your disinterest, so that we could not have contacted you further. Not all conferences are spam.
We have added your email to our unsubscribe database. Please share if you have any other email ids to ensure not to receive any invitations from Drug R&D Boston.

Regards,
Heidi B